Jun Zhang

TL;DR: It is shown that receptor-interacting protein 3 (RIP3) triggers myocardial necroptosis, in addition to apoptosis and inflammation, through activation of Ca2+-calmodulin–dependent protein kinase (CaMKII) rather than through the well-established RIP3 partners RIP1 and MLKL.

TL;DR: It is demonstrated that wild-type SPOP binds to and induces ubiquitination and proteasomal degradation of BET proteins by recognizing a degron motif common among them, and resistance to BET inhibitors in SPOP-mutant prostate cancer can be overcome by combination with AKT inhibitors.

TL;DR: The results of this study show for the first time that isocitrate dehydrogenase 1 and 2 genes are mutated in cholangiocarcinoma, which identifies a new potential target for genotype-directed therapeutic trials and may represent a potential biomarker for earlier detection of cholangsiocARCinoma in a subset of cases.

TL;DR: PTC with a prominent hobnail pattern is a moderately differentiated PTC variant with aggressive clinical behavior and significant mortality.

TL;DR: Using EZH2 antibody-based RNA immunoprecipitation-coupled high throughput sequencing, it is demonstrated that EZh2 binds to MALAT1, a long non-coding RNA (lncRNA) that is overexpressed during PCa progression and that MALat1 plays a vital role in EzH2-enhanced migration and invasion in CRPC cell lines.