Hong Wu

TL;DR: Senescent cells extrude fragments of chromatin from the nucleus into the cytoplasm, where they are processed by an autophagic/lysosomal pathway.

TL;DR: The increased expression of CD166, CD133, and nestin in melanoma suggests that progression to malignant melanoma likely involves genetic pathways instrumental to stem cell biology and normal tissue development.

TL;DR: Increased levels of cyclin D1, resulting from genomic amplification, may contribute to the BRAF inhibitor resistance of BRAF V600E–mutated melanomas, particularly when found in the context of a CDK4 mutation/overexpression.

TL;DR: Gefitinib was well tolerated but had minimal activity in unscreened patients with recurrent ovarian or primary peritoneal carcinoma, and activating mutations in catalytic domain of EGFR in 3.5% of ovarian cancers is the first to document.

TL;DR: It is shown that a decrease in deoxyribonucleotide triphosphate (dNTP) levels underlies oncogene-induced stable senescence-associated cell growth arrest, and suppression of nucleotide metabolism by RRM2 repression is also necessary for maintenance of the stable sen Escherichia-associatedcell growth arrest.