M
Min Xiao
Researcher at Huazhong University of Science and Technology
Publications - 117
Citations - 5273
Min Xiao is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Melanoma & Medicine. The author has an hindex of 27, co-authored 107 publications receiving 3966 citations. Previous affiliations of Min Xiao include University of Texas MD Anderson Cancer Center & University Hospital of Basel.
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Journal ArticleDOI
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
Sydney M. Shaffer,Margaret C. Dunagin,Stefan R. Torborg,Eduardo A. Torre,Benjamin L. Emert,Clemens Krepler,Marilda Beqiri,Katrin Sproesser,Patricia Brafford,Min Xiao,Elliott Eggan,Ioannis N. Anastopoulos,Cesar Augusto Vargas-Garcia,Abhyudai Singh,Katherine L. Nathanson,Meenhard Herlyn,Arjun Raj +16 more
TL;DR: It is shown that human melanoma cells can display profound transcriptional variability at the single-cell level that predicts which cells will ultimately resist drug treatment, and this work reveals the multistage nature of the acquisition of drug resistance and provides a framework for understanding resistance dynamics in single cells.
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Enhancing CD8 + T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.
Ying Zhang,Ying Zhang,Raj K. Kurupati,Ling Liu,Xiangyang Zhou,Gao Zhang,Abeer Hudaihed,Flavia Filisio,Wynetta Giles-Davis,Xiaowei Xu,Giorgos C. Karakousis,Lynn M. Schuchter,Wei Xu,Ravi K. Amaravadi,Min Xiao,Norah Sadek,Clemens Krepler,Meenhard Herlyn,Gordon J. Freeman,Joshua D. Rabinowitz,Hildegund C.J. Ertl +20 more
TL;DR: Using mouse melanoma models, it is reported that CD8+ TILs enhance peroxisome proliferator-activated receptor (PPAR)-α signaling and catabolism of fatty acids (FAs) when simultaneously subjected to hypoglycemia and hypoxia.
Journal ArticleDOI
Activation of Notch1 signaling is required for β-catenin–mediated human primary melanoma progression
Klara Balint,Min Xiao,Chelsea C. Pinnix,Akinobu Soma,Imre Veres,István Juhász,Eric J. Brown,Anthony J. Capobianco,Meenhard Herlyn,Zhao-Jun Liu +9 more
TL;DR: The data suggest a beta-catenin-dependent, stage-specific role for Notch1 signaling in promoting the progression of primary melanoma, andhibiting beta-Catenin expression reversed notch1-enhanced tumor growth and metastasis.
Journal ArticleDOI
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Keiran S.M. Smalley,Mercedes Lioni,Maurizia Dalla Palma,Min Xiao,Brijal Desai,Suzanne Egyhazi,Johan Hansson,Hong Wu,Alastair J. King,Patricia Van Belle,David E. Elder,Keith T. Flaherty,Meenhard Herlyn,Katherine L. Nathanson +13 more
TL;DR: Increased levels of cyclin D1, resulting from genomic amplification, may contribute to the BRAF inhibitor resistance of BRAF V600E–mutated melanomas, particularly when found in the context of a CDK4 mutation/overexpression.
Journal ArticleDOI
Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression.
Zhao-Jun Liu,Min Xiao,Klara Balint,Klara Balint,Keiran S.M. Smalley,Patricia Brafford,Ruihua Qiu,Chelsea C. Pinnix,Xueli Li,Meenhard Herlyn +9 more
TL;DR: It is shown that Notch1 signaling drives the vertical growth phase (VGP) of primary melanoma toward a more aggressive phenotype and regulation of MAPK/PI3K-Akt pathway activities and expression of N-cadherin by the Notch pathway provides a mechanistic basis for Notch signaling in the promotion ofPrimary melanoma progression.