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Zhi Wei

Researcher at New Jersey Institute of Technology

Publications -  202
Citations -  14462

Zhi Wei is an academic researcher from New Jersey Institute of Technology. The author has contributed to research in topics: Genome-wide association study & Cancer. The author has an hindex of 45, co-authored 198 publications receiving 11179 citations. Previous affiliations of Zhi Wei include University of Pennsylvania & Scheie Eye Institute.

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Luke Jostins, +105 more
- 01 Nov 2012 - 
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing

Jason O'Rawe, +17 more
- 27 Mar 2013 - 
TL;DR: The results suggest that more caution should be exercised in genomic medicine settings when analyzing individual genomes, including interpreting positive and negative findings with scrutiny, especially for indels.
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Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

Noam Auslander, +16 more
- 20 Aug 2018 - 
TL;DR: IMPRES is a predictor of ICB response in melanoma which encompasses 15 pairwise transcriptomics relations between immune checkpoint genes and achieves an overall accuracy of AUC = 0.83, outperforming existing predictors and capturing almost all true responders while misclassifying less than half of the nonresponders.
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Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Russell W. Jenkins, +91 more
- 03 Nov 2017 - 
TL;DR: The ability to interrogate ex vivo response to PD-1 blockade using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS) is demonstrated, which represents a novel platform to evaluate ICB using established murine models as well as clinically relevant patient specimens.