H
Hongbo Wang
Researcher at University of Minnesota
Publications - 25
Citations - 915
Hongbo Wang is an academic researcher from University of Minnesota. The author has contributed to research in topics: Aplastic anemia & Transplantation. The author has an hindex of 12, co-authored 22 publications receiving 730 citations. Previous affiliations of Hongbo Wang include Kanazawa University.
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Journal ArticleDOI
Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome
Hongbo Wang,Tatsuya Chuhjo,Tatsuya Chuhjo,Shizuka Yasue,Shizuka Yasue,Mitsuhiro Omine,Mitsuhiro Omine,Shinji Nakao,Shinji Nakao +8 more
TL;DR: The presence of a minor population of P NH-type cells suggests a benign type of bone marrow failure, probably caused by an immunologic mechanism, and peripheral blood should be tested using sensitive flow cytometry for the presence of PNH- type cells in all patients withBone marrow failure before treatment.
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The unexpected effect of cyclosporin A on CD56 + CD16 − and CD56 + CD16 + natural killer cell subpopulations
Hongbo Wang,Bartosz Grzywacz,David J. Sukovich,Valarie McCullar,Qing Cao,Alisa B. Lee,Bruce R. Blazar,David N. Cornfield,Jeffrey S. Miller,Michael R. Verneris +9 more
TL;DR: Collectively, these studies show that CSA influences NK-cell function and phenotype, which may have important implications for graft-versus-leukemia effects.
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iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy.
Frank Cichocki,Ryan Bjordahl,Svetlana Gaidarova,Sajid Mahmood,Ramzey Abujarour,Hongbo Wang,Katie Tuininga,Martin Felices,Zachary Davis,Laura Bendzick,Raedun Clarke,Laurel Stokely,Paul Rogers,Moyar Q. Ge,Megan Robinson,Betsy Rezner,David Robbins,Tom Tong Lee,Dan S. Kaufman,Bruce R. Blazar,Bahram Valamehr,Jeffrey S. Miller +21 more
TL;DR: iNK cells represent an “off-the-shelf” source of cells for immunotherapy with the capacity to target tumors and engage the adaptive arm of the immune system to make a “cold” tumor “hot” by promoting the influx of activated T cells to augment checkpoint inhibitor therapies.
Journal ArticleDOI
Relative increase of granulocytes with a paroxysmal nocturnal haemoglobinuria phenotype in aplastic anaemia patients: the high prevalence at diagnosis.
Hongbo Wang,Tatsuya Chuhjo,Hirohito Yamazaki,Shintaro Shiobara,Masanao Teramura,Hideaki Mizoguchi,Shinji Nakao +6 more
TL;DR: It is suggested that a relative increase in the number of PNH granulocytes is a common feature of AA at diagnosis, and that it may represent the presence of immunologic pressure to normal haematopoietic stem cells as a cause of AA.
Journal ArticleDOI
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
Karrune Woan,Hansol Kim,Ryan Bjordahl,Zachary Davis,Svetlana Gaidarova,John Goulding,Brian Hancock,Sajid Mahmood,Ramzey Abujarour,Hongbo Wang,Katie Tuininga,Bin Zhang,Cheng-Ying Wu,Behiye Kodal,Melissa Khaw,Laura Bendzick,Paul Rogers,Moyar Q. Ge,Greg Bonello,Miguel Meza,Martin Felices,Janel Huffman,Thomas Dailey,Tom Tong Lee,Bruce Walcheck,Karl J. Malmberg,Bruce R. Blazar,Yenan T. Bryceson,Bahram Valamehr,Jeffrey S. Miller,Frank Cichocki +30 more
TL;DR: In this article, a triple-gene-edited induced pluripotent stem cell (iPSC) line was generated to express a high affinity, non-cleavable version of the Fc receptor CD16a and a membrane bound interleukin (IL)-15/IL-15R fusion protein.