The unexpected effect of cyclosporin A on CD56 + CD16 − and CD56 + CD16 + natural killer cell subpopulations
Hongbo Wang,Bartosz Grzywacz,David J. Sukovich,Valarie McCullar,Qing Cao,Alisa B. Lee,Bruce R. Blazar,David N. Cornfield,Jeffrey S. Miller,Michael R. Verneris +9 more
TLDR
Collectively, these studies show that CSA influences NK-cell function and phenotype, which may have important implications for graft-versus-leukemia effects.About:
This article is published in Blood.The article was published on 2007-09-01 and is currently open access. It has received 125 citations till now. The article focuses on the topics: Interleukin 21 & Interleukin 12.read more
Citations
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Journal ArticleDOI
Targeting natural killer cells and natural killer T cells in cancer.
TL;DR: The rational use of these cells in cancer immunotherapies awaits a better understanding of their effector functions, migratory patterns and survival properties in humans.
Journal ArticleDOI
Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection
Sandra López-Vergès,Jeffrey M. Milush,Brian S. Schwartz,Marcelo J. Pando,Jessica Jarjoura,Vanessa A. York,Jeffrey P. Houchins,Steve Miller,Sang-Mo Kang,Phillip J. Norris,Douglas F. Nixon,Lewis L. Lanier +11 more
TL;DR: The preferential expansion of a unique subset of NK cells coexpressing the activating CD94–NKG2C receptor and CD57 in CMV+ donors is demonstrated and it is proposed that CD57 might provide a marker of “memory” NK cells that have been expanded in response to infection.
Book ChapterDOI
ErbB Receptors and Cancer
TL;DR: The ErbB receptor family, also known as the EGF receptor family or type I receptorfamily, includes the epidermal growth factor (EGF) receptor (EGFR), which has been the primary choices as targets for developing cancer therapies.
Journal ArticleDOI
Phase 1 clinical trial using mbIL21 ex vivo-expanded donor-derived NK cells after haploidentical transplantation.
Stefan O. Ciurea,Jolie Schafer,Roland L. Bassett,Cecele J. Denman,Kai Cao,Dana Willis,Gabriela Rondon,Julianne Chen,Doris Soebbing,Indreshpal Kaur,Alison M. Gulbis,Sairah Ahmed,Katayoun Rezvani,Elizabeth J. Shpall,Dean A. Lee,Richard E. Champlin +15 more
TL;DR: This trial demonstrated production feasibility and safety of infusing high doses of ex vivo-expanded NK cells after haploidentical HSCT without adverse effects, increased GVHD, or higher mortality, and was associated with significantly improved NK-cell number and function, lower viral infections, and low relapse rate posttransplant.
Journal ArticleDOI
Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion
Franco Locatelli,Pietro Merli,Daria Pagliara,Giuseppina Li Pira,Michela Falco,Daniela Pende,Roberto Rondelli,Barbarella Lucarelli,Letizia Pomponia Brescia,Riccardo Masetti,Giuseppe Milano,Valentina Bertaina,Mattia Algeri,Rita Maria Pinto,Luisa Strocchio,Raffaella Meazza,L. Grapulin,Rupert Handgretinger,Alessandro Moretta,Alice Bertaina,Lorenzo Moretta +20 more
TL;DR: The data indicate that haplo-HSCT after αβ T- and B-cell depletion represents a competitive alternative for children with AL in need of urgent allograft.
References
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Journal ArticleDOI
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
TL;DR: A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+ using an 8-coordinate tetracarboxylate chelating site with stilbene chromophores that offer up to 30-fold brighter fluorescence.
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Jun Liu,Jesse D. Farmer,Willam S. Lane,Jeffrey S. Friedman,Irving L. Weissman,Stuart L. Schreiber +5 more
TL;DR: The results suggest that calcineurin is involved in a common step associated with T cell receptor and IgE receptor signaling pathways and that cyclophilin and FKBP mediate the actions of CsA and Fk506 by forming drug-dependent complexes with and altering the activity of calcineURin-calmodulin.
Journal ArticleDOI
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
Loredana Ruggeri,Marusca Capanni,Elena Urbani,Katia Perruccio,Warren D. Shlomchik,Antonella Tosti,Sabrina Posati,Daniela Rogaia,Francesco Frassoni,Franco Aversa,Massimo F. Martelli,Andrea Velardi +11 more
TL;DR: It is shown that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD in human transplants and in mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GV HD.
Book ChapterDOI
Biology of natural killer cells.
TL;DR: The existence of NK cells has prompted a reinterpretation of both the studies of specific cytotoxicity against spontaneous human tumors and the theory of immune surveillance, at least in its most restrictive interpretation.
Journal ArticleDOI
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
TL;DR: An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.
Related Papers (5)
Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.
Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation.
Loredana Ruggeri,Marusca Capanni,Marusca Capanni,Myriam Casucci,Myriam Casucci,Isabella Volpi,Isabella Volpi,Antonella Tosti,Antonella Tosti,Katia Perruccio,Katia Perruccio,Elena Urbani,Elena Urbani,Robert S. Negrin,Robert S. Negrin,Massimo F. Martelli,Massimo F. Martelli,Andrea Velardi,Andrea Velardi +18 more