H
Hongdi Gu
Researcher at University of Washington
Publications - 4
Citations - 377
Hongdi Gu is an academic researcher from University of Washington. The author has contributed to research in topics: Folding (chemistry) & Protein folding. The author has an hindex of 4, co-authored 4 publications receiving 374 citations.
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Kinetics of folding of the IgG binding domain of peptostreptoccocal protein L
TL;DR: Comparing results on the structurally and functionally similar IgG binding domain of streptococcal protein G show intriguing differences in the folding of the two proteins, suggesting a partial collapse of the unfolded chain may occur under these conditions.
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The sequences of small proteins are not extensively optimized for rapid folding by natural selection
TL;DR: The folding thermodynamics and kinetics of 12 heavily mutated variants of the small IgG binding domain of protein L retrieved from high-complexity combinatorial libraries are reported by using a phage-display selection for proper folding that does not discriminate between rapidly and slowly folding proteins.
Journal ArticleDOI
Contrasting roles for symmetrically disposed β-turns in the folding of a small protein
TL;DR: The results demonstrate that the role of beta-turns in protein folding is strongly context-dependent, and suggests that the first turn is formed and the second turn disrupted in the folding transition state.
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Robustness of protein folding kinetics to surface hydrophobic substitutions
TL;DR: This work uses both combinatorial and site‐directed mutagenesis to explore the consequences of surface hydrophobic substitutions for the folding of two small single domain proteins, the src SH3 domain, and the IgG binding domain of Peptostreptococcal protein L.