H
Hongfeng Deng
Researcher at GlaxoSmithKline
Publications - 24
Citations - 1814
Hongfeng Deng is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Cannabinoid & Receptor. The author has an hindex of 18, co-authored 24 publications receiving 1689 citations. Previous affiliations of Hongfeng Deng include University of Connecticut.
Papers
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Journal ArticleDOI
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
Mohab M. Ibrahim,Hongfeng Deng,Alexander Zvonok,Debra A. Cockayne,Joyce Kwan,Heriberto P. Mata,Todd W. Vanderah,Josephine Lai,Frank Porreca,Alexandros Makriyannis,T. Philip Malan +10 more
TL;DR: AM1241 dose-dependently reversed tactile and thermal hypersensitivity produced by ligation of the L5 and L6 spinal nerves in rats, demonstrating a mechanism leading to the inhibition of pain, one that targets receptors localized exclusively outside the CNS.
Journal ArticleDOI
CB2 cannabinoid receptor-mediated peripheral antinociception.
T. Philip Malan,Mohab M. Ibrahim,Hongfeng Deng,Qian Liu,Heriberto P. Mata,Todd W. Vanderah,Frank Porreca,Alexandros Makriyannis +7 more
TL;DR: Using AM1241, a CB2 receptor‐selective agonist, it is demonstrated that CB2 receptors produce antinociception to thermal stimuli and the local, peripheral nature of CB2 cannabinoid antinOCiception is demonstrated.
Journal ArticleDOI
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
Hongfeng Deng,Heather O’Keefe,Christopher P. Davie,Kenneth E Lind,Raksha A. Acharya,G Joseph Franklin,J. Larkin,Rosalie Matico,Michael Neeb,Monique M Thompson,Thomas Lohr,Jeffrey W. Gross,Paolo A. Centrella,Gary K. O’Donovan,Katie L Sargent Bedard,Kurt van Vloten,Sibongile Mataruse,Steven R. Skinner,Svetlana L. Belyanskaya,Tiffany Carpenter,Todd W Shearer,Matthew A. Clark,John W. Cuozzo,Christopher C. Arico-Muendel,Barry A. Morgan +24 more
TL;DR: This study provides the first small molecule evidence for the critical role of ADAMTS-5 in human cartilage degradation by employing encoded library technology (ELT), which enables affinity selection of small molecule binders from complex mixtures by DNA tagging.
Patent
Cannabimimetic indole derivatives
TL;DR: In this article, a novel cannabimimetic indole derivatives are presented which have preferentially high affinities for one of the cannabinoid CB1 or CB2 receptor sites.
Journal ArticleDOI
Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
Jian Lin,Hongfeng Deng,Lei Jin,Pramod Pandey,Jesse Quinn,Susan M. Cantin,Michael J. Rynkiewicz,Joan C. Gorga,Frank Bibbins,Cassandra Celatka,Pamela Nagafuji,Thomas D. Bannister,Harold V Meyers,Robert E. Babine,Neil J Hayward,David R. Weaver,Howard Benjamin,Frans L Stassen,Sherin S. Abdel-Meguid,James E. Strickler +19 more
TL;DR: The data suggest that factor XIa plays a significant role in venous thrombosis and may be a suitable target for the development of antithrombotic therapy.