H
Hongwu Chen
Researcher at University of California, Davis
Publications - 100
Citations - 11058
Hongwu Chen is an academic researcher from University of California, Davis. The author has contributed to research in topics: Cancer & Nuclear receptor. The author has an hindex of 41, co-authored 86 publications receiving 10098 citations. Previous affiliations of Hongwu Chen include University at Buffalo & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
Laszlo Nagy,Laszlo Nagy,Peter Tontonoz,Peter Tontonoz,Jacqueline G.A Alvarez,Hongwu Chen,Ronald M. Evans,Ronald M. Evans +7 more
TL;DR: The data suggest that the biologic effects of oxLDL are coordinated by two sets of receptors, one on the cell surface, which binds and internalizes the particle, and one in the nucleus, which is transcriptionally activated by its component lipids.
Journal ArticleDOI
Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300
Hongwu Chen,Richard J. Lin,Richard J. Lin,R. Louis Schiltz,Debabrata Chakravarti,Alyssa Nash,Laszlo Nagy,Martin L. Privalsky,Yoshihiro Nakatani,Ronald M. Evans +9 more
TL;DR: It is shown that purified ACTR is a potent histone acetyltransferase and appears to define a distinct evolutionary branch to this recently described family of coactivator complex.
Journal ArticleDOI
Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.
Hongwu Chen,Richard J. Lin,Richard J. Lin,Wen Xie,Damien Wilpitz,Ronald M. Evans,Ronald M. Evans +6 more
TL;DR: In exploring the underlying mechanism, it is found that the acetylase ACTR can be acetylated by p300/CBP, and this results provide strong in vivo evidence that histone acetylation plays a key role in hormone-induced gene activation and defines cofactor acetylations as a novel regulatory mechanism in hormonal signaling.
Journal ArticleDOI
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators
Stephen J. Demarest,Maria A. Martinez-Yamout,John Chung,Hongwu Chen,Hongwu Chen,Wei Xu,H. Jane Dyson,Ronald M. Evans,Peter E. Wright +8 more
TL;DR: This study uncovers a unique mechanism, called ‘synergistic folding’, through which p160 coactivators recruit CBP/p300 to allow transmission of the hormonal signal to the transcriptional machinery.
Journal ArticleDOI
A Transcriptional Switch Mediated by Cofactor Methylation
Wei Xu,Hongwu Chen,Keyong Du,Hiroshi Asahara,Marc Tini,Beverly M. Emerson,Marc Montminy,Ronald M. Evans +7 more
TL;DR: Strong in vivo and in vitro evidence that histone methylation plays a key role in hormone-induced gene activation is provided and cofactor methylation is defined as a new regulatory mechanism in hormone signaling.