Hongyang Wang

TL;DR: It is shown that cationic lipid-mediated in vivo delivery of Cas9–guide RNA–lipid complexes can ameliorate hearing loss in a mouse model of human genetic deafness, suggesting that protein–RNA complex delivery of target gene-disrupting agents in vivo is a potential strategy for the treatment of some types of autosomal-dominant hearing loss.

TL;DR: The studies indicate that canalostomy can be a viable route for safe and efficient gene delivery, and they expand the repertoire of AAVs to target diverse cell types in the adult inner ear.

TL;DR: Inspired by the physiological structures of peripheral nerves, a conductive topological scaffold for nerve repair is presented by modifying Morpho butterfly wing with reduced graphene oxide (rGO) nanosheets and methacrylated gelatin (GelMA) hydrogel encapsulated brain-derived neurotrophic factor (BDNF) and electrically conductive NGCs based on the rGO/BDNF/Gelma-integrated Morpho Butterfly wing are demonstrated.

TL;DR: In this paper , the TMC1 p.1253 T > A (p.M418K) mutation is homologous to that in Beethoven mice, which may induce autosomal dominant non-syndromic progressive hearing loss.

TL;DR: It is suggested that subclinical hyperthyroidism may be a neglected phenotype of PRKAR1A gene variants and a novel component of CNC patients.