Shiming Yang

TL;DR: It is shown that cationic lipid-mediated in vivo delivery of Cas9–guide RNA–lipid complexes can ameliorate hearing loss in a mouse model of human genetic deafness, suggesting that protein–RNA complex delivery of target gene-disrupting agents in vivo is a potential strategy for the treatment of some types of autosomal-dominant hearing loss.

TL;DR: In patients with undeveloped vestibular/oval windows and inaccessible round windows, Vibrant Soundbridge implantation performed by placing the transducer into a reconstructed window on the inner tympanum wall demonstrated significant improvement in hearing and verbal communication ability.

TL;DR: It is reported that quantitative changes in the number of IHC ribbon synapses and hearing loss occur in response to gentamicin treatment in mice, and ribbon synaptic plasticity may require the quantitative changes to play self-protective role adapted to ototoxic aminoglycoside stimuli.

TL;DR: Noise exposure can cause a decline in cochlear ribbon synapses and result in consequent hearing loss and the reduction of synaptic puncta appears reversible and may contribute to hearing restoration in mice after noise exposure, according to a study of C57BL/6J mice.

TL;DR: The present 26-electrode cochlear implant has already helped to lower the price of co chlear implantation in China and will likely contribute to increased cochLear implant access and success in the rest of the world.