H
Horia Todor
Researcher at University of California, San Francisco
Publications - 18
Citations - 826
Horia Todor is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 14 publications receiving 584 citations. Previous affiliations of Horia Todor include Duke University & National Institutes of Health.
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Journal ArticleDOI
Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis
Byoung-Mo Koo,George Kritikos,Jeremiah D. Farelli,Horia Todor,Kenneth Tong,Harvey Kimsey,Ilan Wapinski,Marco Galardini,Angelo Cabal,Jason M. Peters,Anna-Barbara Hachmann,David Z. Rudner,Karen N. Allen,Athanasios Typas,Carol A. Gross +14 more
TL;DR: Two ordered, barcoded, erythromycin-resistance- and kanamycin-Resistance-marked single-gene deletion libraries of the Gram-positive model organism, Bacillus subtilis, are constructed and a suite of high-throughput phenotyping methodologies are described to provide a genome-wide analysis of competence and sporulation.
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Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation.
Daniel M. Barrett,Stephen M. Black,Horia Todor,Rupert Schmidt-Ullrich,Kathryn S. Dawson,Ross B. Mikkelsen +5 more
TL;DR: One consequence of oxidative stimulation of NO generation is S-nitrosylation and inhibition of PTPs critical in cellular signal transduction pathways, which support the conclusion that a mild oxidative signal is converted to a nitrosative one due to the better redox signaling properties of NO.
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Hsp104 overexpression cures Saccharomyces cerevisiae [PSI+] by causing dissolution of the prion seeds.
Yang-Nim Park,Xiaohong Zhao,Yang-In Yim,Horia Todor,Robyn E. Ellerbrock,Michael Reidy,Evan Eisenberg,Daniel C. Masison,Lois E. Greene +8 more
TL;DR: This work found that neither the kinetics of curing nor the heterogeneity in the distribution of the green fluorescent protein (GFP)-labeled Sup35 foci in partially cured yeast cells is compatible with Hsp104 overexpression curing [PSI+] by inhibiting severing.
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Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.
John S. Hawkins,Melanie R. Silvis,Byoung-Mo Koo,Jason M. Peters,Hendrik Osadnik,Marco Jost,Cameron C. Hearne,Jonathan S. Weissman,Horia Todor,Carol A. Gross +9 more
TL;DR: A modified CRISPRi system leveraging the predictable reduction in efficacy of imperfectly matched sgRNAs to generate defined levels of CRISpri activity is developed and its broad applicability is demonstrated.
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A transcription factor links growth rate and metabolism in the hypersaline adapted archaeon Halobacterium salinarum
TL;DR: It is demonstrated that TrmB regulates the gluconeogenic production of sugars incorporated into the cell surface S‐layer glycoprotein, and it is shown thattrmB–DNA binding correlates with instantaneous growth rate, likely because S‐ layer glycosylation is proportional to growth.