H
Howard J. Goldberg
Researcher at University of Toronto
Publications - 35
Citations - 2881
Howard J. Goldberg is an academic researcher from University of Toronto. The author has contributed to research in topics: Mesangial cell & Protein kinase C. The author has an hindex of 25, co-authored 35 publications receiving 2747 citations. Previous affiliations of Howard J. Goldberg include Mount Sinai Hospital, Toronto & University Health Network.
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Journal ArticleDOI
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
Xue Liang Du,Diane Edelstein,Luciano Rossetti,I. G. Fantus,Howard J. Goldberg,Fuad N. Ziyadeh,Jie Wu,Michael Brownlee +7 more
TL;DR: Hyperglycemia-induced mitochondrial superoxide overproduction increases hexosamine synthesis and O-glycosylation of Sp1, which activates expression of genes that contribute to the pathogenesis of diabetic complications.
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Extracellular Signal-regulated Kinase and the Small GTP-binding Protein, Rac, Contribute to the Effects of Transforming Growth Factor-β1 on Gene Expression
TL;DR: Findings indicate that TGF-β1 modulates gene expression partly through ERK and Rac in NIH 3T3 cells, and indicates that the kinases and regulatory proteins that convey signals initiated by transforming growth factor-β to the nucleus are poorly characterized.
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Thioredoxin-interacting Protein Mediates High Glucose-induced Reactive Oxygen Species Generation by Mitochondria and the NADPH Oxidase, Nox4, in Mesangial Cells
Anu Shah,Ling Xia,Ling Xia,Howard J. Goldberg,Howard J. Goldberg,Ken W. Lee,Susan E. Quaggin,Susan E. Quaggin,I. George Fantus +8 more
TL;DR: TxNIP deficiency protects mesangial cells from HG-induced oxidative stress and increased collagen by blocking mitochondrial glucose metabolism, NADPH oxidase, and Nox4 by regulating the TCA cycle versus glycolytic glucose flux.
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Inhibition of Src Kinase Blocks High Glucose–Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice
Kanta Taniguchi,Ling Xia,Ling Xia,Ling Xia,Howard J. Goldberg,Howard J. Goldberg,Howard J. Goldberg,Ken W.K. Lee,Anu Shah,Laura Stavar,Elodie A.Y. Masson,Elodie A.Y. Masson,Elodie A.Y. Masson,Abdul Momen,Abdul Momen,Eric A. Shikatani,Eric A. Shikatani,Rohan John,Mansoor Husain,Mansoor Husain,I. George Fantus +20 more
TL;DR: Data indicate a role for Src in a high glucose-Src-TACE-heparin-binding epidermal growth factor-EGFR-MAPK–signaling pathway to collagen accumulation, which may provide a novel therapeutic target for diabetic nephropathy.
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Reduced cyclosporin accumulation in multidrug-resistant cells.
TL;DR: The results suggest that cellular cyclosporine accumulation is regulated at least in part by its interaction with P-glycoprotein.