H
Howard J. Gritton
Researcher at Boston University
Publications - 55
Citations - 2060
Howard J. Gritton is an academic researcher from Boston University. The author has contributed to research in topics: Cholinergic & Optogenetics. The author has an hindex of 18, co-authored 46 publications receiving 1502 citations. Previous affiliations of Howard J. Gritton include University of Illinois at Urbana–Champaign & University of Michigan.
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Journal ArticleDOI
Beyond the connectome: the dynome.
TL;DR: A framework for studying the brain's "dynome" and its relationship to cognition is described, which links brain connectivity with brain dynamics, as well as the biological details that relate this connectivity more directly to function.
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Modulators in concert for cognition: modulator interactions in the prefrontal cortex.
TL;DR: This review will paradigmatically focus on neuromodulator interactions in the PFC and be further constrained by an additional focus on their role in cognitive functions.
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Population imaging of neural activity in awake behaving mice
Kiryl D. Piatkevich,Kiryl D. Piatkevich,Seth Bensussen,Hua-an Tseng,Sanaya N. Shroff,Violeta G. Lopez-Huerta,Demian Park,Demian Park,Erica E. Jung,Erica E. Jung,Or A. Shemesh,Or A. Shemesh,Christoph Straub,Howard J. Gritton,Michael Romano,Emma K. Costa,Bernardo L. Sabatini,Zhanyan Fu,Edward S. Boyden,Xue Han +19 more
TL;DR: A genetically encoded fluorescent voltage indicator, SomArchon, which exhibits millisecond response times and is compatible with optogenetic control, and which increases the sensitivity, signal-to-noise ratio, and number of neurons observable several-fold over previously published fully genetically encoded reagents is described.
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Cortical cholinergic signaling controls the detection of cues
Howard J. Gritton,William M. Howe,Caitlin S. Mallory,Vaughn L. Hetrick,Joshua D. Berke,Martin Sarter +5 more
TL;DR: Cholinergic transients were generated in mice performing a task necessitating the reporting of cue and noncue events, and may be essential for synchronizing cortical neuronal output driven by salient cues and executing cue-guided responses.
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Acetylcholine Release in Prefrontal Cortex Promotes Gamma Oscillations and Theta-Gamma Coupling during Cue Detection
William M. Howe,Howard J. Gritton,Nicholas A. Lusk,Erik A. Roberts,Vaughn L. Hetrick,Joshua D. Berke,Joshua D. Berke,Martin Sarter +7 more
TL;DR: Using a combination of in vivo neurochemistry, neurophysiology, and pharmacological methods, it is demonstrated that cue-evoked acetylcholine release, through distinct actions at both nicotinic and muscarinic receptors, triggers a procession of neural oscillations that map onto the multiple stages of cue detection.