H
Howard Jones
Researcher at Merck & Co.
Publications - 126
Citations - 2353
Howard Jones is an academic researcher from Merck & Co.. The author has contributed to research in topics: Alkyl & Alkoxy group. The author has an hindex of 25, co-authored 126 publications receiving 2322 citations.
Papers
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Journal ArticleDOI
Inhibitory Effect of the TRFK-5 Anti-IL-5 Antibody in a Guinea Pig Model of Asthma
Peter J. Mauser,Aileen Pitman,Angela Witt,Xiomara Fernandez,J. A. Zurcher,Ted T. Kung,Howard Jones,Arthur S. Watnick,Robert W. Egan,William Kreutner,G. Kenneth Adams +10 more
TL;DR: A critical and possibly independent role for IL-5 in allergic airway hyperresponsiveness and the accumulation of eosinophils within the lung of the guinea pig is suggested.
Journal ArticleDOI
Involvement of il-5 in a murine model of allergic pulmonary inflammation :prophylactic and therapeutic effect of an anti-il-5 antibody
Ted T. Kung,D. Stelts,J. A. Zurcher,G K Adams,Robert W. Egan,William Kreutner,Arthur S. Watnick,Howard Jones,Richard W. Chapman +8 more
TL;DR: An important role for IL-5 is demonstrated in the development of eosinophilic inflammation of the airways and for the migration of eOSinophils from the bone marrow into blood in response to antigen challenge.
Journal ArticleDOI
Mast cells modulate allergic pulmonary eosinophilia in mice.
Ted T. Kung,D. Stelts,J. A. Zurcher,Howard Jones,Shelby P. Umland,William Kreutner,Robert W. Egan,Richard W. Chapman +7 more
TL;DR: The role of mast cells on the development of IgE-mediated allergic pulmonary eosinophilia in vivo was evaluated and levels of serum IgE and IgG1 were not different between W/Wv mice and their congenic littermates.
Journal ArticleDOI
Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung.
A. Gulbenkian,Robert W. Egan,Xiomara Fernandez,Howard Jones,William Kreutner,Ted T. Kung,F. Payvandi,L. Sullivan,J. A. Zurcher,Arthur S. Watnick +9 more
TL;DR: The importance of IL-5 to pulmonary eosinophilia in challenged, allergic guinea pigs is demonstrated by demonstrating the importance of an experimentally irrelevant, isotype-matched antibody from GL113 cells or with heat-denaturedIL-5 antibody was without effect.
Patent
Substituted indenyl acetic acids
TL;DR: In this article, the authors present a survey of INDENYL ACETIC ACIDS and non-toXIC PHARMACEUTICALLY ACCEPTABLE AMIDES, ESTERS, and SALTS.