R
Robert W. Egan
Researcher at Schering-Plough
Publications - 155
Citations - 11059
Robert W. Egan is an academic researcher from Schering-Plough. The author has contributed to research in topics: Interleukin 5 & Receptor. The author has an hindex of 54, co-authored 155 publications receiving 10790 citations.
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Journal ArticleDOI
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
Paul Van Eerdewegh,Randall D. Little,Josée Dupuis,Richard G. Del Mastro,Kathy Falls,Jason Simon,Dana Torrey,Sunil Pandit,Joyce McKenny,Karen Braunschweiger,Alison Walsh,Ziying Liu,Brooke Hayward,Colleen Folz,Susan P. Manning,Alicia Bawa,Lisa Saracino,Michelle Thackston,Youssef Benchekroun,Neva J. Capparell,Mei Wang,Ron Adair,Yun Feng,Joann Dubois,Michael Fitzgerald,Hui Huang,Rene Gibson,Kristina Allen,Alex Pedan,Melvyn R. Danzig,Shelby P. Umland,Robert W. Egan,Cuss Francis M,S. Rorke,Joanne B. Clough,John W. Holloway,Stephen T. Holgate,Tim Keith +37 more
TL;DR: In this article, the authors performed a genome-wide scan on 460 Caucasian families and identified a locus on chromosome 20p13 that was linked to asthma (log 10 of the likelihood ratio (LOD), 2.94 and bronchial hyperresponsiveness (LOD, 3.93).
Journal ArticleDOI
Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms.
TL;DR: Electrophoretic mobility shift assays suggest that inhibition of NFκB activation may be an important mechanism for IL-10 supression of cytokine gene transcription in human monocytes.
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Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils: Involvement of phosphatidate phosphohydrolase in signal transduction
TL;DR: The results demonstrate that the fMLP-induced PLD utilizes diradyl-PC as the major substrate and alkyl-PA is degraded by a phosphohydrolase to produce alkyL-DG, which is derived almost exclusively from PC via the PLD/PA phosphohydrology pathway.
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The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti-α4β7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases
TL;DR: The pharmacologic properties of vedolizumab, in conjunction with the gastrointestinal tropism of α4β7 integrin function, may ultimately confer an improved risk-to-benefit profile for patients with inflammatory bowel diseases.
Journal Article
IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells.
TL;DR: The present study provides the first evidence that, in human PBMCs, IL-10 inhibits cytokine synthesis by acting mainly at the level of cytokine gene transcription.