Hu Xu

TL;DR: It is found that chronic angiotensin II infusion of mice with vascular smooth muscle cell (VSMC)-specific EP4 gene knockout frequently developed aortic dissection (AD) with severe elastic fiber degradation and VSMC dedifferentiation, and EP4 may represent a potential therapeutic target for the treatment of AD.

TL;DR: It is found that the expression of all EP3 isoforms were downregulated in WAT of both db/db and high-fat diet-induced obese mice, suggesting that EP3 receptor and its α and γ isoforms are involved in both adipogenesis and lipolysis and influence food intake, serum lipid levels, and insulin sensitivity.

TL;DR: The results suggest that increased hepatocellular cholesterol storage and cholesterol availability with the enhanced liver regeneration are identified in Srebp-1c-/- mice and shows that providing requisite cholesterol levels to proliferating hepatocytes and keeping appropriate cholesterol metabolism are required for normal liver regeneration.

TL;DR: It is found that treatment with T0901317, a nonspecific LXR agonist, increased both 17β-HSD13 mRNA and protein levels in cultured hepatocytes and demonstrates that LXRα activation induces 17 β- HSD13 expression in a SREBP-1c-dependent manner.

TL;DR: These findings demonstrate that endothelial EP4 is essential for BP homeostasis and markedly decreased NO contents in blood vessels via reducing eNOS phosphorylation at Ser1177.