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Wen Su
Researcher at Shenzhen University
Publications - 27
Citations - 829
Wen Su is an academic researcher from Shenzhen University. The author has contributed to research in topics: Fatty liver & Nonalcoholic fatty liver disease. The author has an hindex of 13, co-authored 25 publications receiving 560 citations. Previous affiliations of Wen Su include Peking University & University of Houston.
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Journal ArticleDOI
Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.
Wen Su,Yang Wang,Xiao Jia,Wenhan Wu,Linghai Li,Xiaodong Tian,Sha Li,Chunjiong Wang,Hua-Min Xu,Jiaqi Cao,Qifei Han,Shimeng Xu,Yong Chen,Yanfeng Zhong,Xiaoyan Zhang,Pingsheng Liu,Jan-Åke Gustafsson,Youfei Guan +17 more
TL;DR: The aim of this study was to determine the function of 17β-hydroxysteroid dehydrogenase-13 (17β-HSD13), one of the authors' newly identified LD-associated proteins in human subjects with normal liver histology and simple steatosis, in NAFLD development.
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FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis
Chunjiong Wang,Yujing Chi,Jing Li,Yifei Miao,Sha Li,Wen Su,Shi Jia,Zhenzhen Chen,Shengnan Du,Xiaoyan Zhang,Yunfeng Zhou,Wenhan Wu,Mingyan Zhu,Zhiwei Wang,Huaqian Yang,Guoheng Xu,Shiqiang Wang,Jichun Yang,Youfei Guan +18 more
TL;DR: FAM3A plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PI3K‐Akt signaling pathway by way of a Ca2+/CaM‐dependent mechanism.
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Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis
Xiaoyan Zhang,Sha Li,Yunfeng Zhou,Wen Su,Xiongzhong Ruan,Bing Wang,Feng Zheng,Margaret Warner,Jan-Åke Gustafsson,Youfei Guan +9 more
TL;DR: It is shown that hepatic CYP4A expression was up-regulated in the livers of patients and three murine models of NAFLD and may represent a potential therapeutic target for the treatment ofNAFLD.
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VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure
Hu Xu,Shengnan Du,Bingying Fang,Chaojie Li,Xiao Jia,Senfeng Zheng,Sai-Lun Wang,Qingwei Li,Wen Su,Nanping Wang,Feng Zheng,Lihong Chen,Xiaoyan Zhang,Jan-Åke Gustafsson,Jan-Åke Gustafsson,Youfei Guan +15 more
TL;DR: It is found that chronic angiotensin II infusion of mice with vascular smooth muscle cell (VSMC)-specific EP4 gene knockout frequently developed aortic dissection (AD) with severe elastic fiber degradation and VSMC dedifferentiation, and EP4 may represent a potential therapeutic target for the treatment of AD.
Journal ArticleDOI
Aquaporins in the kidney: physiology and pathophysiology.
TL;DR: This review summarizes current understanding of physiological and pathophysiological roles of AQPs in the kidney, with a focus on recent progress on AQP2 regulation by the nuclear receptor transcriptional factors.