H
Hua Guo
Researcher at Jilin University
Publications - 13
Citations - 210
Hua Guo is an academic researcher from Jilin University. The author has contributed to research in topics: Apoptosis & Transfection. The author has an hindex of 6, co-authored 12 publications receiving 115 citations. Previous affiliations of Hua Guo include University of Louisville & Ningbo University.
Papers
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Journal ArticleDOI
Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis.
Junlian Gu,Shudong Wang,Hua Guo,Yi Tan,Yi Tan,Yaqin Liang,Anyun Feng,Qiuju Liu,Chendil Damodaran,Zhiguo Zhang,Bradley B. Keller,Chi Zhang,Lu Cai,Lu Cai +13 more
TL;DR: Targeted inhibition of p53 in diabetic individuals may provide a novel approach for the prevention of diabetic cardiomyopathy (DCM).
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Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function.
Zhuo Li,Zhuo Li,Hua Guo,Hua Guo,Jia Li,Jia Li,Tianjiao Ma,Tianjiao Ma,Shanshan Zhou,Shanshan Zhou,Zhiguo Zhang,Lining Miao,Lu Cai +12 more
TL;DR: SFN prevention of T2D-induced renal lipotoxicity was associated with AMPK-mediated activation of lipid metabolism and Nrf2-dependent anti-oxidative function in wild-type mice, but not in SFN-treated Ampkα2-/- mice.
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Murine double minute 2 siRNA and wild-type p53 gene therapy enhances sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy in vitro and in vivo.
TL;DR: Results indicate that cisplatin chemotherapy combined with targeting the MDM2/p53 axis is an attractive strategy to treat SKOV3/DDP cancer.
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4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress.
Tianjiao Ma,Zongyu Zheng,Hua Guo,Xin Lian,Madhavi J. Rane,Lu Cai,Ki Soo Kim,Kyoung Tae Kim,Zhiguo Zhang,Liqi Bi +9 more
TL;DR: 4‐O‐methylhonokiol (MH) prevented T2D‐induced renal injury and showed the preventive effect of MH on the renal oxidative stress and inflammation in DN.
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Murine double minute 2 siRNA and wild-type p53 gene therapy interact positively with zinc on prostate tumours in vitro and in vivo.
Junlian Gu,Bo Wang,Yanan Liu,Lingzhi Zhong,Yufeng Tang,Hua Guo,Tao Jiang,Liwei Wang,Yang Li,Lu Cai +9 more
TL;DR: The findings suggest that the combined therapy of Pmp53 with zinc is an effective strategy that may open a new therapeutic avenue in some cancers expressing low levels of zinc and a defective P53 status.