H
Hua He
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 85
Citations - 2064
Hua He is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 18, co-authored 49 publications receiving 1523 citations. Previous affiliations of Hua He include University of Cincinnati.
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Journal ArticleDOI
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease
Leah C. Kottyan,Leah C. Kottyan,Benjamin P. Davis,Joseph D. Sherrill,Kan Liu,Mark Rochman,Kenneth M. Kaufman,Kenneth M. Kaufman,Matthew T. Weirauch,Samuel E. Vaughn,Sara Lazaro,Sara Lazaro,Andrew M. Rupert,Mojtaba Kohram,Emily M. Stucke,Katherine A. Kemme,Albert F. Magnusen,Albert F. Magnusen,Hua He,Phillip Dexheimer,Mirna Chehade,Robert A. Wood,Robbie D. Pesek,Brian P. Vickery,David Fleischer,Robert Lindbad,Hugh A. Sampson,Vincent A. Mukkada,Phil E. Putnam,J. Pablo Abonia,Lisa J. Martin,John B. Harley,John B. Harley,Marc E. Rothenberg +33 more
TL;DR: A model to explain the tissue-specific nature of EoE that involves the interplay of allergic sensitization with an Eosinophilic esophagitis-specific, IL-13–inducible esophageal response involving CAPN14 is proposed.
Journal ArticleDOI
Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis
Joseph D. Sherrill,Peisong Gao,Emily M. Stucke,Carine Blanchard,Margaret H. Collins,Phil E. Putnam,James P. Franciosi,Jonathan P. Kushner,J. Pablo Abonia,Amal Assa'ad,Melinda Butsch Kovacic,Jocelyn M. Biagini Myers,Bruce S. Bochner,Hua He,Gurjit K. Khurana Hershey,Lisa J. Martin,Marc E. Rothenberg +16 more
TL;DR: TSLP is identified as a candidate gene critically involved in EE susceptibility beyond its role in promoting T(H)2 responses, and the induction of the candidate gene in primary esophageal epithelial cells is examined.
Journal ArticleDOI
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring
Margaret H. Collins,Lisa J. Martin,Eileen S. Alexander,Eileen S. Alexander,J. Todd Boyd,Rachel Sheridan,Hua He,Scott Pentiuk,P.E. Putnam,J. P. Abonia,Vincent A. Mukkada,James P. Franciosi,Marc E. Rothenberg +12 more
TL;DR: The EoE histology scoring system provides a method to objectively assess histologic changes in the esophagus beyond eosinophil number, and discriminates treated from untreated patients, uses features commonly found in such biopsies, and is utilizable by pathologists after minimal training.
Journal ArticleDOI
Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis.
Eileen S. Alexander,Eileen S. Alexander,Lisa J. Martin,Margaret H. Collins,Leah C. Kottyan,Heidi Sucharew,Hua He,Vincent A. Mukkada,Paul A. Succop,J. Pablo Abonia,Heather Foote,Michael D. Eby,Tommie M. Grotjan,Alexandria J. Greenler,Evan S. Dellon,Jeffrey G. Demain,Glenn T. Furuta,Larry E. Gurian,John B. Harley,John B. Harley,Russell J. Hopp,Amir F. Kagalwalla,Amir F. Kagalwalla,Ajay Kaul,Kari C. Nadeau,Kari C. Nadeau,Richard J. Noel,Richard J. Noel,Philip E. Putnam,Karl F. von Tiehl,Marc E. Rothenberg +30 more
TL;DR: EoE RRRs are increased 10- to 64-fold compared with the general population, and greater birth weight difference between twins, breast-feeding, and fall birth season were associated with twin discordance in disease status.
Journal ArticleDOI
Functional Variant in the Autophagy-Related 5 Gene Promotor is Associated with Childhood Asthma
Lisa J. Martin,Jayanta Gupta,S. Jyothula,Melinda Butsch Kovacic,Jocelyn M. Biagini Myers,Tia L. Patterson,Mark B. Ericksen,Hua He,Aaron M. Gibson,Tesfaye M. Baye,Sushil Amirisetty,Anna M. Tsoras,Youbao Sha,N. Tony Eissa,Gurjit K. Khurana Hershey +14 more
TL;DR: Genetic variants in ATG5, including a functional promotor variant, are associated with childhood asthma, providing novel evidence for a role for AtG5 in childhood asthma.