P
Peisong Gao
Researcher at Johns Hopkins University School of Medicine
Publications - 103
Citations - 5891
Peisong Gao is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Immunoglobulin E & Population. The author has an hindex of 37, co-authored 95 publications receiving 4919 citations. Previous affiliations of Peisong Gao include Johns Hopkins University & Swansea University.
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Journal ArticleDOI
Cytokine modulation of atopic dermatitis filaggrin skin expression
Michael D. Howell,Byung Eui Kim,Peisong Gao,Audrey V. Grant,Mark Boguniewicz,A. DeBenedetto,Lynda C. Schneider,Lisa A. Beck,Kathleen C. Barnes,Donald Y.M. Leung +9 more
TL;DR: Patients with AD have an acquired defect in filaggrin expression that can be modulated by the atopic inflammatory response, and neutralization of IL-4 and IL-13 could improve skin barrier integrity.
Journal ArticleDOI
Genetic variants of IL-13 signalling and human asthma and atopy
Andrea Heinzmann,X. Q. Mao,Mina Akaiwa,R. T. Kreomer,Peisong Gao,Koichi Ohshima,R. Umeshita,R. Umeshita,Yoshito Abe,Sandra Braun,Tetsuji Yamashita,Mark H. Roberts,Rie Sugimoto,Kazuhiko Arima,Yojiro Arinobu,Bin Yu,S. Kruse,Tadao Enomoto,Y. Dake,M. Kawai,S. Shimazu,S. Sasaki,Chaker N. Adra,M. Kitaichi,Hiroshi Inoue,Kohei Yamauchi,Nobukazu Tomichi,Fumihiko Kurimoto,Naotaka Hamasaki,Julian M. Hopkin,Kenji Izuhara,T. Shirakawa,Klaus A. Deichmann +32 more
TL;DR: Detailed molecular modelling analyses indicate that residue 110 of IL-13, the site of the charge-modifying variants Arg and Gln, is important in the internal constitution of the ligand and crucial in ligand-receptor interaction, likely to be important promoters of human asthma.
Journal ArticleDOI
Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis
Joseph D. Sherrill,Peisong Gao,Emily M. Stucke,Carine Blanchard,Margaret H. Collins,Phil E. Putnam,James P. Franciosi,Jonathan P. Kushner,J. Pablo Abonia,Amal Assa'ad,Melinda Butsch Kovacic,Jocelyn M. Biagini Myers,Bruce S. Bochner,Hua He,Gurjit K. Khurana Hershey,Lisa J. Martin,Marc E. Rothenberg +16 more
TL;DR: TSLP is identified as a candidate gene critically involved in EE susceptibility beyond its role in promoting T(H)2 responses, and the induction of the candidate gene in primary esophageal epithelial cells is examined.
Journal ArticleDOI
Macrophage polarization and allergic asthma
TL;DR: Modulation of macrophage phenotypes through molecular intervention by targeting some of those potential macrophAGE regulators may have therapeutic potential in the treatment of allergic asthma and other allergic diseases.
Journal ArticleDOI
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum.
Peisong Gao,Nicholas Rafaels,T. Hand,Tanda Murray,Mark Boguniewicz,Tissa Hata,Lynda C. Schneider,Jon M. Hanifin,Richard L. Gallo,Li Gao,Terri H. Beaty,Lisa A. Beck,Kathleen C. Barnes,Donald Y.M. Leung +13 more
TL;DR: The R501X mutation in the gene encoding filaggrin, one of the strongest genetic predictors of AD, confers an even greater risk for ADEH in both European and African ancestry populations, suggesting a role for defective skin barrier in this devastating condition.