Hua Wu

TL;DR: [68Ga]Ga-DOTA-FAPI-04 PET/CT showed a superior diagnostic efficacy than [18F] FDGPET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer, especially in identifying liver metastases, peritoneal carcinomatosis, and brain tumours.

TL;DR: In patients undergoing oncological evaluation with inconclusive [ 18 F]FDG PET/CT findings, [ 68 Ga]Ga-DOTA-FAPI-04 may have a complementary role in discriminating mass lesions on conventional imaging, locating the primary site of unknown malignancy, modifying tumour staging, and detecting suspected disease recurrence.

TL;DR: The literature for the state-of-the-art FAPI-PET imaging for cancer diagnosis compared with fluorodeoxyglucose (FDG)-PET is summarized and the use of FAP-PET for therapeutic regimen improvement and fibroblast activation protein (FAP)-targeted molecule modification strategies is summarized.

TL;DR: [Ga]Ga-DOTA-FAPI-04 PET/CT showed higher tracer uptake in tuberculous lesions in the lung, spines, and brain than did [F]FDG PET/ CT; such imaging modality may be useful for determinWeipeng Huang and Haojun Chen contributed equally to this work.

TL;DR: The results demonstrate that the inhibitory and promotion effect of MED on LPS-stimulated inflammatory mediators and anti-inflammatory factor production in BV2 microglia is associated with the suppression of the NF-κB, ERK1/2 and TLR signaling pathways.