Yuemao Shen

TL;DR: The octaketide cytosporone B (Csn-B) is a naturally occurring agonist for Nur77 that induced apoptosis and retarded xenograft tumor growth by inducing Nur77 expression, translocating Nur77 to mitochondria to cause cytochrome c release and may be useful as a reagent to increase understanding of Nur77 biological function.

TL;DR: The genetic data demonstrate that the four redox genes, in addition to the PKS/NRPS gene and the sterol desaturase/fatty acid hydroxylase gene, are required for HSAF production, and reveal a previously unrecognized biosynthetic mechanism for hybrid PK/NRP in prokaryotic organisms.

TL;DR: A snapshot of the important work done on the lysobacterial natural products is provided to provide useful information for future biosynthetic engineering of novel antibiotics in Lysobacter.

TL;DR: The structure of one of the accumulated compounds together with (18)O experiments suggests that this oxidative cyclization produces an 8-hydroxy-7, 8-dihydronaphthoquinone structure that, after the stage of proansamycin X, is dehydrogenated to an 8.hydroxynaphthOquinone.

TL;DR: Five new verticillin-type epipolysulfanydioxopiperazines were isolated from wheat solid-substrate fermentation of Gliocladium roseum 1A, and all nine compounds exhibited antinematodal activity against Caenorhabditis elegans and Panagrellus redivivus.