The integration of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic therapy (CDT) holds great promise for enhanced anticancer effects. Herein, we report biodegradable cancer cell membrane-coated mesoporous copper/manganese silicate nanospheres (mCMSNs) with homotypic targeting ability to the cancer cell lines and enhanced ROS generation through singlet oxygen (1O2) production and glutathione (GSH)-activated Fenton reaction, showing excellent CDT/PDT synergistic therapeutic effects. We demonstrate that mCMSNs are able to relieve the tumor hypoxia microenvironment by catalytic decomposition of endogenous H2O2 to O2 and further react with O2 to produce toxic 1O2 with a 635 nm laser irradiation. GSH-triggered mCMSNs biodegradation can simultaneously generate Fenton-like Cu+ and Mn2+ ions and deplete GSH for efficient hydroxyl radical (•OH) production. The specific recognition and homotypic targeting ability to the cancer cells were also revealed. Notably, relieving hypoxia an...

Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief.

Activation of persulfates to degrade refractory organic pollutants is currently a hot topic of advanced oxidation. Developing simple and effective activation approaches is crucial for the practical application of persulfates. We report in this research that trace cupric species (Cu(II) in several μM) can efficiently trigger peroxymonosulfate (PMS) oxidation of various organic pollutants under slightly alkaline conditions. The intermediate oxidant dominating this process was investigated with electron paramagnetic resonance (EPR), chemical probing, and in situ Raman spectroscopy. Unlike conventional PMS activation, which generates sulfate radical, hydroxyl radical, or singlet oxygen as major oxidants, Cu(III) was confirmed to be the primary and selective intermediate oxidant during the Cu(II)/PMS oxidation. Hydroxyl radical is the secondary intermediate oxidant formed from the reaction of Cu(III) with OH-. Hybrid oxidation by the two oxidants imparts Cu(II)/PMS with high efficiency in the degradation of a series of pollutants. The results of this work suggest that, with no need of introducing complex catalysts, trace Cu(II) inherent in or artificially introduced to some water or wastewater can effectively trigger PMS oxidation of organic pollutants.

Trace Cupric Species Triggered Decomposition of Peroxymonosulfate and Degradation of Organic Pollutants: Cu(III) Being the Primary and Selective Intermediate Oxidant

Laccases are a family of copper-containing oxidases with important applications in bioremediation and other various industrial and biotechnological areas. There have been over two dozen reviews on laccases since 2010 covering various aspects of this group of versatile enzymes, from their occurrence, biochemical properties and expression to immobilization and applications. This review is not intended to be all-encompassing; instead, we highlighted some of the latest developments in basic and applied laccase research with an emphasis on laccase-mediated bioremediation of pharmaceuticals, especially antibiotics. Pharmaceuticals are a broad class of emerging organic contaminants that are recalcitrant and prevalent. The recent surge in the relevant literature justifies a short review on the topic. Since low laccase yields in natural and genetically modified hosts constitute a bottleneck to industrial-scale applications, we also accentuated a genus of laccase-producing white-rot fungi, Cerrena, and included a discussion with regards to regulation of laccase expression.

/pdf/laccases-production-expression-regulation-and-applications-2phhq4fkoa.pdf

Laccases: Production, expression regulation, and applications in pharmaceutical biodegradation

Laccases and peroxidases: The smart, greener and futuristic biocatalytic tools to mitigate recalcitrant emerging pollutants

Application of advanced oxidation processes and toxicity assessment of transformation products.

This study investigated the degradation of perfluorooctanesulfonate (PFOS) in a reactive electrochemical membrane (REM) system in which a porous Magneli phase titanium suboxide ceramic membrane ser...

Degradation of Perfluorooctanesulfonate by Reactive Electrochemical Membrane Composed of Magnéli Phase Titanium Suboxide

Bicarbonate enhanced removal of triclosan by copper(II) catalyzed Fenton-like reaction in aqueous solution

Bioaccumulation mechanism of organophosphate esters in adult zebrafish (Danio rerio).

Removal of triclosan via peroxidases-mediated reactions in water: Reaction kinetics, products and detoxification

Our recent findings indicate effective electrochemical degradation of perfluoroalkyl acids (PFAAs) in aqueous solutions using novel titanium suboxide (TSO) anodes. This provides a potentially promising technology to treat per- and polyfluoroalkyl substances (PFASs) in legacy AFFF stockpiles or in wastewater and contaminated groundwater. The degradation of PFAAs in TSO-based electrooxidation was evaluated with solutions of different compositions containing eight PFAAs either individually or in a mixture and under a range of operation conditions. Surface area normalized pseudo-first order rate constants were obtained and interpreted in terms of PFAA degradation behaviors and mechanisms. The PFAA degradation rates were further correlated to the molecular and electronic descriptors of the chemicals calculated based on density functional theory. The results of this study further the understanding of PFAS degradation in TSO-based anodic oxidation and provide a basis for process optimization, design and scaling.

Huanhuan Shi

Papers

Degradation of Perfluorooctanesulfonate by Reactive Electrochemical Membrane Composed of Magnéli Phase Titanium Suboxide

Bicarbonate enhanced removal of triclosan by copper(II) catalyzed Fenton-like reaction in aqueous solution

Bioaccumulation mechanism of organophosphate esters in adult zebrafish (Danio rerio).

Removal of triclosan via peroxidases-mediated reactions in water: Reaction kinetics, products and detoxification

Electrochemical degradation of perfluoroalkyl acids by titanium suboxide anodes