Huaping Tang

TL;DR: Genetic studies in Drosophila have identified serine proteases and serpins that regulate activation of PO and melanization in vivo, and these studies have provided new insight into the role that melanization plays in fighting microbial infection.

TL;DR: The genetic characterization of two immune inducible serine proteases, MP1 and MP2, which act in a melanization cascade regulated by Spn27A are described, which plays an important role in augmenting the effectiveness of other immune reactions, thereby promoting resistance of Drosophila to microbial infection.

TL;DR: Unexpectedly, it is found that tracheal melanization resulting from Spn77Ba disruption induces systemic expression of the antifungal peptide Drosomycin via the Toll pathway, which could represent an alarm mechanism that prepares the host in case a pathogen breaches epithelial defenses to invade internal tissues.

TL;DR: Evidence of therapeutic potential for the selective PKC (protein kinase C) inhibitor sotrastaurin (STN) in preclinical models ofDLBCL is offered and it is found that STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL.

TL;DR: It is demonstrated that the so far uncharacterized Serpin-28D (Spn28D, CG7219) regulates the proPO cascade in both hemolymph and tracheal compartments and supports a model in which Spn 28D confines PO availability by controlling its initial release, while Spn27A is rather limiting the melanization reaction to the wound site.