H
Hubert Barucki
Researcher at Cardiff University
Publications - 9
Citations - 469
Hubert Barucki is an academic researcher from Cardiff University. The author has contributed to research in topics: Bicyclic molecule & Varicella zoster virus. The author has an hindex of 6, co-authored 9 publications receiving 463 citations. Previous affiliations of Hubert Barucki include Rega Institute for Medical Research.
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Journal ArticleDOI
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain
Christopher McGuigan,Hubert Barucki,Sally Blewett,A Carangio,Jonathan T. Erichsen,Graciela Andrei,Robert Snoeck,E. De Clercq,Jan Balzarini +8 more
TL;DR: From a range of DNA and RNA viruses tested, only VZV was inhibited by these compounds indicating their extreme selectivity for this target virus.
Journal ArticleDOI
Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
Christopher McGuigan,Christopher John Yarnold,Garry Jones,Sonsoles Velázquez,Hubert Barucki,Andrea Brancale,Graciela Andrei,Robert Snoeck,Erik De Clercq,Jan Balzarini +9 more
TL;DR: The synthesis and characterization of a series of chain-modified analogues based on novel deoxynucleoside analogues with unusual bicyclic base moieties and their extensive in vitro evaluation make them of great interest for possible antiviral drug development.
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Fluorescent bicyclic furo pyrimidine deoxynucleoside analogs as potent and selective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles
Christopher McGuigan,Andrea Brancale,Hubert Barucki,Subashini Srinivasan,Garry Jones,Ranjith N. Pathirana,Sally Blewett,Raquel Álvarez,Christopher John Yarnold,A Carangio,Sonsoles Velázquez,Graciela Andrei,Robert Snoeck,Erik De Clercq,Jan Balzarini +14 more
Journal ArticleDOI
Furano pyrimidines as novel potent and selective anti-VZV agents
Christopher McGuigan,Andrea Brancale,Hubert Barucki,Sheila Srinivasan,G. Jones,Ranjith N. Pathirana,A Carangio,Sally Blewett,G Luoni,O Bidet,A. Jukes,C. A. Jarvis,Graciela Andrei,Robert Snoeck,E. De Clercq,Jan Balzarini +15 more
TL;DR: The discovery, synthesis, characterization, antiviral profile, SAR, mechanism of action and development prospects for this new family of antivirals are reviewed.
Journal ArticleDOI
Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective varicella-zoster virus inhibitors.
Sally Blewett,Christopher McGuigan,Hubert Barucki,Graciela Andrei,Robert Snoeck,Erik De Clercq,Jan Balzarini +6 more
TL;DR: A series of alkoxyphenyl compounds and two halophenyl derivatives were successfully synthesised and displayed anti-VZV activity at low μM concentrations.