Huei-Min Lin

TL;DR: These studies emphasize TGF-β/Smad3 signaling as an important regulator of insulin gene transcription and β-cell function and suggest that components of the T GF-β signaling pathway may be dysregulated in diabetes.

TL;DR: Although TGF-beta still remains elusive in terms of the authors' understanding of its multifunctional modes of action, research is moving closer to the design of approaches directed toward modulating its activities for therapeutic benefit.

TL;DR: In this paper, the authors illustrate a function for Cdks in regulating the subcellular localization of retinoblastoma (RB) tumor suppressor protein and uncover a novel mechanism to circumvent RB-mediated growth suppression by altered nucleocytoplasmic trafficking via the Exportin1 pathway.

TL;DR: It is proposed that RB inactivation, via aberrant nucleocytoplasmic transport, may disrupt normal cell differentiation programs and accelerate the cancer process, and is evidence that tumor cells modulate the protein transport machinery thereby making theprotein transport process a viable therapeutic target.

TL;DR: A 165-base pair fragment from -111 to +54 relative to the dihydrofolate reductase initiation site was shown to be sufficient for transcriptional activity in either direction, suggesting that expression of the two divergent genes is regulated by a bidirectional promoter that may use common regulatory elements.