S
Sushil G. Rane
Researcher at National Institutes of Health
Publications - 53
Citations - 4831
Sushil G. Rane is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cell cycle & Cellular differentiation. The author has an hindex of 28, co-authored 50 publications receiving 4269 citations. Previous affiliations of Sushil G. Rane include Temple University.
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Journal ArticleDOI
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia.
TL;DR: Results establish Cdk4 as an essential regulator of specific cell types as well as establishing its role as a regulator of insulin-deficient diabetes and pancreatic hyperplasia in mice expressing a mutant Cdk 4 that cannot bind the cell-cycle inhibitor P16INK4a.
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Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling
Hariom Yadav,Celia Quijano,Celia Quijano,Anil K. Kamaraju,Oksana Gavrilova,Rana Malek,Weiping Chen,Patricia M. Zerfas,Duan Zhigang,Elizabeth C. Wright,Christina H. Stuelten,Peter D. Sun,Scott Lonning,Monica C. Skarulis,Anne E. Sumner,Toren Finkel,Sushil G. Rane +16 more
TL;DR: It is demonstrated that TGF-β signaling regulates glucose tolerance and energy homeostasis and suggested that modulation of T GF-β activity might be an effective treatment strategy for obesity and diabetes.
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Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion
TL;DR: It is demonstrated that the administration of a probiotic, VSL#3, prevented and treated obesity and diabetes in several mouse models and suggested that probiotics can modulate the gut microbiota-SCFA-hormone axis.
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Janus kinases: components of multiple signaling pathways
Sushil G. Rane,E P Reddy +1 more
TL;DR: It has been found that JAK kinase function is required for optimal activation of the Src-kinase cascade, the Ras-MAP kinase pathway, the PI3K-AKT pathway and STAT signaling following the interaction of cytokine/interferon receptors with their ligands.
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Hematopoietic cytokine receptor signaling.
TL;DR: This recent discovery, when coupled with the fact that STATs are activated by oncoproteins such as BCR-ABL, underscores the importance of the JAK-STAT pathway in both normal cellular development and disease states.