H
Hugues Miel
Researcher at University College Cork
Publications - 6
Citations - 1080
Hugues Miel is an academic researcher from University College Cork. The author has contributed to research in topics: Aminopyridines & Organic synthesis. The author has an hindex of 4, co-authored 5 publications receiving 823 citations. Previous affiliations of Hugues Miel include University of Caen Lower Normandy.
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Modern Organic Synthesis with α-Diazocarbonyl Compounds
TL;DR: This work aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical properties of EMTs and their applications in the context of drug discovery and development.
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Modern Organic Synthesis with α‐Diazocarbonyl Compounds
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A versatile synthesis of 2-amino-4H-pyrido[1,2-a][1,3,5]triazin-4-ones from 2-aminopyridines
TL;DR: The quasi-one pot synthesis of new 2-aminopyrido[1,2-a][1,3,5]triazin-4-ones starting from 2-amino-pyridine and 2aminopicolines is described in this article in order to obtain a library of cyclic guanidines.
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N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc
TL;DR: The N-Boc 4-nitropiperidine analogue of the eastern part of maraviroc was synthesized in two steps from N-boc-piperidone as mentioned in this paper.
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Abstract LB022: A novel first-in-class USP19 inhibitor for the treatment of cancer-induced muscle atrophy
Natalie Page,Vignesh Karthikaisamy,Darren M O'Hara,Aaron Cranston,Colin O'Dowd,Xavier Jacq,Richard D A Wilkinson,Stephanie Burton,Hayley Gibson,Joana Costa,Daniel B. Longley,S Shepherd,Christina Bell,Peter Hewitt,Mary McFarland,Hugues Miel,Steven K Whitehead,Lauren Proctor,Shane Rountree,Mark Wappett,Mauricio Berriel Diaz,Stephan Herzig,Tim Harrison +22 more
TL;DR: In this paper , the authors reported the discovery of a novel, highly potent and selective inhibitor of USP19 (ADC-846) and demonstrate its utility in a cancer-induced muscle atrophy model in vivo.