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Stephan Herzig
Researcher at Heidelberg University
Publications - 176
Citations - 10185
Stephan Herzig is an academic researcher from Heidelberg University. The author has contributed to research in topics: Adipose tissue & Insulin resistance. The author has an hindex of 44, co-authored 155 publications receiving 8461 citations. Previous affiliations of Stephan Herzig include Technische Universität München & Salk Institute for Biological Studies.
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Journal ArticleDOI
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Stephan Herzig,Fanxin Long,Fanxin Long,Ulupi S. Jhala,Susan Hedrick,Rebecca Quinn,Anton Bauer,Dorothea Rudolph,Günther Schütz,Cliff H. Yoon,Pere Puigserver,Bruce M. Spiegelman,Marc Montminy +12 more
TL;DR: Fasting hyperglycaemia* is strongly correlated with type II diabetes, so the results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease.
Journal ArticleDOI
TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver
TL;DR: It is shown that TRB3, a mammalian homolog of Drosophila tribbles, functions as a negative modulator of Akt, which contributes to insulin resistance in individuals with susceptibility to type II diabetes.
Journal ArticleDOI
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
Seung Hoi Koo,Hiroaki Satoh,Stephan Herzig,Chih-Hao Lee,Susan Hedrick,Rohit N. Kulkarni,Ronald M. Evans,Jerrold M. Olefsky,Marc Montminy +8 more
TL;DR: It is shown that, in the liver, TRB-3 is a target for PPAR-α, a fasting-inducible inhibitor of the serine-threonine kinase Akt/PKB, which indicates a link between nuclear hormone receptor and insulin signaling pathways, and suggest a potential role for TRb-3 inhibitors in the treatment of type 2 diabetes.
Journal ArticleDOI
Glucocorticoids, metabolism and metabolic diseases
TL;DR: This review focuses on the role of the GC-GR axis for metabolic homeostasis and dysregulation, emphasizing tissue-specific functions of GCs in the control of energy metabolism.
Journal ArticleDOI
Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes
Alexandros Vegiopoulos,Karin Müller-Decker,Daniela Strzoda,Iris Schmitt,Evgeny Chichelnitskiy,Anke Ostertag,Mauricio Berriel Diaz,Jan Rozman,Martin Hrabé de Angelis,Rolf M. Nüsing,Carola W. Meyer,Walter Wahli,Martin Klingenspor,Stephan Herzig +13 more
TL;DR: Studying mouse models, it is shown that cyclooxygenase (COX)–2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of β-adrenergic signaling in WAT and is required for the induction of BAT in Wat depots, which suggests that the PG pathway regulates systemic energy homeostasis.