Hui-Chao Lin

TL;DR: The nucleolin-blocking experiments unambiguously evidenced that the formed nanomedicine could target to the cell surface via the specific AS1411-nucleolin interaction, which increased the efficiency of cell uptake and produced cytotoxic reactive oxygen species efficiently by irradiation of visible light for establishing a new type of PDT to cancer cells.

TL;DR: The constructed Fe3O4@TiO2-DNM NPs have been endowed with multifunctions that allow them to selectively deliver combinatorial therapeutic payload and exhibit integrated therapeutic effectiveness to tumors.

TL;DR: This new nucleic acid conjugated SPION nanocarrier successfully integrates dual-targeted, dual-therapy and pH stimuli responsive drug release, into one single system, and thus maybe an ideal drug delivery vehicle with great potential in the era of precision medicine.

TL;DR: The results indicate that the fabricated protoporphyrin IX aptamer-coated upconversion nanoparticle nanoplatform has higher efficiency, lower toxicity, and less side effects compared to the free photosensitizer protoporalin IX, and thus is a new promising photodynamic therapy agent especially for the deep-seated tumors.

TL;DR: The present data suggest that the CaCO3 coating and folic acid modification of MMSN are able to create a targeted, pH-sensitive template for drug delivery system with application in cancer therapy.