J
Jianliang Shen
Researcher at Chinese Academy of Sciences
Publications - 117
Citations - 4680
Jianliang Shen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Self-healing hydrogels & Drug delivery. The author has an hindex of 30, co-authored 111 publications receiving 2832 citations. Previous affiliations of Jianliang Shen include Houston Methodist Hospital & Sun Yat-sen University.
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Journal ArticleDOI
Safety of Nanoparticles in Medicine.
Joy Wolfram,Motao Zhu,Yong Yang,Jianliang Shen,Jianliang Shen,Emanuela Gentile,Donatella Paolino,Massimo Fresta,Guangjun Nie,Chunying Chen,Haifa Shen,Haifa Shen,Mauro Ferrari,Mauro Ferrari,Yuliang Zhao +14 more
TL;DR: The mechanisms for molecular, cellular, organ, and immune system toxicity, which can be observed with a subset of nanoparticles, are discussed and important considerations for nanoparticle safety assessment are reviewed.
Journal ArticleDOI
An injectable nanoparticle generator enhances delivery of cancer therapeutics
Rong Xu,Rong Xu,Rong Xu,Guodong Zhang,Guodong Zhang,Junhua Mai,Junhua Mai,Xiaoyong Deng,Xiaoyong Deng,Xiaoyong Deng,Victor Segura-Ibarra,Suhong Wu,Jianliang Shen,Haoran Liu,Zhenhua Hu,Lingxiao Chen,Yi Huang,Eugene J. Koay,Eugene J. Koay,Yu Huang,Yu Huang,Jun Liu,Joe Ensor,Elvin Blanco,Xuewu Liu,Mauro Ferrari,Mauro Ferrari,Haifa Shen,Haifa Shen +28 more
TL;DR: Compared to its individual components or current therapeutic formulations, iNPG-pDox shows enhanced efficacy in MDA-MB-231 and 4T1 mouse models of metastatic breast cancer, including functional cures in 40–50% of treated mice.
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Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics.
Shengzhe Zhao,Shengzhe Zhao,Shengzhe Zhao,Xujiang Yu,Yuna Qian,Wei Chen,Jianliang Shen,Jianliang Shen +7 more
TL;DR: The latest biomedical application including responsive MRI, multimodal imaging, nanozyme, MHT, photo-responsive therapy and drug delivery, the mechanism of corresponding treatments and cooperation therapies of multifunctional Fe3O4 NPs are explained.
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Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics
Jianliang Shen,Han Cheon Kim,Hua Su,Feng Wang,Joy Wolfram,Dickson K. Kirui,Junhua Mai,Chaofeng Mu,Liang-Nian Ji,Zong-Wan Mao,Haifa Shen +10 more
TL;DR: A universal siRNA carrier consisting of a mesoporous silica nanoparticle functionalized with cyclodextrin-grafted polyethylenimine (CP), which provides positive charge for loading of siRNA through electrostatic interaction and enables effective endosomal escape of si RNA.
Journal ArticleDOI
Co-Delivery of Cisplatin Prodrug and Chlorin e6 by Mesoporous Silica Nanoparticles for Chemo-Photodynamic Combination Therapy to Combat Drug Resistance
Wei Zhang,Jianliang Shen,Hua Su,Ge Mu,Jing-Hua Sun,Cai-Ping Tan,Xing-Jie Liang,Liang-Nian Ji,Zong-Wan Mao +8 more
TL;DR: A novel nanoscale drug delivery system (nDDS) based nanotherapeutic that combines chemotherapy and photodynamic therapy into one single platform to achieve synergistic anticancer capacity to conquer cisplatin resistance is reported.