Hui Hou

TL;DR: A virtual profiling model against a panel of 391 kinases based on large-scale bioactivity data and the multitask deep neural network algorithm is presented to create a comprehensive kinome interaction network for designing novel chemical modulators or drug repositioning.

TL;DR: In this paper, the KU complex was found abundantly expressed in the cytoplasm, where it recognized accumulated cyTOPlasmic DNA in aged human and mouse CD4+ T-cells.

TL;DR: In this article, the authors show that the internalization of Gram-negative bacterial outer membrane vesicles (OMVs) in human intestinal epithelial cells promotes recruitment of caspase-5 and PIKfyve to early endosomal membranes via sorting nexin 10 (SNX10), resulting in LPS release from OMVs into the cytosol.

TL;DR: The discovery of triazoloquinoxaline 1a is described as a novel STING agonist possessing the potential to be further developed for antiviral and antitumor treatment via Structure-based Virtual Screening.

TL;DR: Based on the crystal structure of SR-717 bound to hSTING, a series of bipyridazine derivatives were designed and synthesized as highly potent STING agonists as discussed by the authors .