Hui-Qian Duan

TL;DR: Upregulated glycolysis in the lesioned muscle tissues of DM/PM was revealed, which activated the NLRP3 inflammasome and leaded to pyroptosis in muscle cells.

TL;DR: The findings indicate that the immunostaining of inflammatory markers such as MHC-I, M HC-II, CD4, CD8, CD303 and MAC are of diagnostic value for IIMs regardless of the immunosuppression regime and disease duration.

TL;DR: It is proposed that MADD with peripheral neuropathy may be a new phenotypic subtype because the pathology and reaction to riboflavin treatment are different from those of traditional MADD, although further research on the precise pathogenesis and mechanisms is needed.

TL;DR: DYSF is upregulated and exhibits a potential role along with that of HLA-A and MCP-1 in inflammatory cell infiltration and muscle damage during the development of DM/PM.

TL;DR: In this paper, the authors established the clinicopathological-genetic spectrum of titinopathy from a single neuromuscular center and found that TTN mutations are more likely to be responsible for an increasing proportion of various myopathies, such as hereditary myopathy with early respiratory failure (HMERF), core myopathy and distal myopathy, than currently recognized mutations.