Hui Tian

TL;DR: By acting as ligands for GPCRs, succinate and α-ketoglutarate are found to have unexpected signalling functions beyond their traditional roles and it is shown that succinate increases blood pressure in animals.

TL;DR: Kynurenic acid stimulates [35S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment, and inhibits lipopolysaccharide-induced tumor necrosis factor-α secretion in peripheral blood mononuclear cells.

TL;DR: In a mouse in vivo model, the activation of GPR43 by acetate results in the reduction in plasma free fatty acid levels without inducing the flushing side effect that has been observed by theactivation of nicotinic acid receptor, GPR109A.

TL;DR: This work identifies glial cell-derived neurotrophic factor receptor alpha-like (GFRAL) as a brainstem-restricted receptor for growth and differentiation factor 15 (GDF15), and identifies a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress.

TL;DR: A role for GPR84 is indicated in directly linking fatty acid metabolism to immunological regulation and it is demonstrated that medium-chain FFAs amplify lipopolysaccharide-stimulated production of the proinflammatory cytokine interleukin-12 p40 through GPR 84.