J
Jer-Yuan Hsu
Researcher at University of California, San Diego
Publications - 21
Citations - 3305
Jer-Yuan Hsu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Promoter & Transcription factor II D. The author has an hindex of 14, co-authored 20 publications receiving 2961 citations. Previous affiliations of Jer-Yuan Hsu include University of Virginia & University of Virginia Health System.
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Journal ArticleDOI
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.
Jer-Yuan Hsu,Zu-Wen Sun,Xiumin Li,Melanie Reuben,Kelly Tatchell,Douglas K. Bishop,Jeremy M. Grushcow,Cynthia J. Brame,Jennifer A. Caldwell,Donald F. Hunt,Rueyling Lin,M. Mitchell Smith,C. David Allis +12 more
TL;DR: An enzyme system that regulates chromosome dynamics and controls histone phosphorylation that is conserved among diverse eukaryotes is revealed.
Journal ArticleDOI
Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14
Wan-Sheng Lo,Raymond C. Trievel,J.R. Rojas,Laura J. Duggan,Jer-Yuan Hsu,C. David Allis,Ronen Marmorstein,Shelley L. Berger +7 more
TL;DR: Observations suggest that transcriptional regulation occurs by multiple mechanistically linked covalent modifications of histones, including serine 10 to alanine in the histone H3 tail.
Journal ArticleDOI
The RNA Polymerase II Core Promoter – the Gateway to Transcription
TL;DR: The core promoter is a sophisticated gateway to transcription that determines which signals will lead to transcription initiation and may contain many different sequence motifs that specify different mechanisms of transcription and responses to enhancers.
Journal ArticleDOI
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
Jer-Yuan Hsu,Suzanne Christine Crawley,Michael Chen,Dina A. Ayupova,Darrin A. Lindhout,Higbee Jared Martin,Alan Kutach,William Joo,Zhengyu Gao,Diana Fu,Carmen To,Kalyani Mondal,Betty Chan Li,Avantika Kekatpure,Marilyn Wang,Teresa Laird,Geoffrey Horner,Jackie Chan,Michele McEntee,Manuel E. Lopez,Damodharan Lakshminarasimhan,Andre White,Sheng-Ping Wang,Jun Yao,Junming Yie,Hugo Matern,Mark J. Solloway,Raj Haldankar,Tom Parsons,Jie Tang,Wenyan D. Shen,Yu Alice Chen,Hui Tian,Bernard B. Allan +33 more
TL;DR: This work identifies glial cell-derived neurotrophic factor receptor alpha-like (GFRAL) as a brainstem-restricted receptor for growth and differentiation factor 15 (GDF15), and identifies a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress.
Journal ArticleDOI
Sterile 20 Kinase Phosphorylates Histone H2B at Serine 10 during Hydrogen Peroxide-Induced Apoptosis in S. cerevisiae
Sung-Hee Ahn,Sung-Hee Ahn,Wang L. Cheung,Jer-Yuan Hsu,Robert L. Diaz,M. Mitchell Smith,C. David Allis,C. David Allis +7 more
TL;DR: Conservation of targeted H2B phosphorylation and the enzyme system responsible for the process point to an ancient mechanism of chromatin remodeling that likely plays an important role in governing cellular homeostasis in a wide range of organisms.