H
Hui Tian
Researcher at Amgen
Publications - 44
Citations - 5361
Hui Tian is an academic researcher from Amgen. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 26, co-authored 43 publications receiving 4686 citations.
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Journal ArticleDOI
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
Weihai He,Frederick Jia-Pei Miao,Daniel C.-H. Lin,Ralf T. Schwandner,Zhulun Wang,Jinhai Gao,Jin-Long Chen,Hui Tian,Lei Ling +8 more
TL;DR: By acting as ligands for GPCRs, succinate and α-ketoglutarate are found to have unexpected signalling functions beyond their traditional roles and it is shown that succinate increases blood pressure in animals.
Journal ArticleDOI
Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35
Jinghong Wang,Nicole Simonavicius,Xiaosu Wu,Gayathri Swaminath,Jeff D. Reagan,Hui Tian,Lei Ling +6 more
TL;DR: Kynurenic acid stimulates [35S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment, and inhibits lipopolysaccharide-induced tumor necrosis factor-α secretion in peripheral blood mononuclear cells.
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Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids
Hongfei Ge,Xiaofan Li,Jennifer Weiszmann,Ping Wang,Helene Baribault,Jin-Long Chen,Hui Tian,Yang Li +7 more
TL;DR: In a mouse in vivo model, the activation of GPR43 by acetate results in the reduction in plasma free fatty acid levels without inducing the flushing side effect that has been observed by theactivation of nicotinic acid receptor, GPR109A.
Journal ArticleDOI
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
Jer-Yuan Hsu,Suzanne Christine Crawley,Michael Chen,Dina A. Ayupova,Darrin A. Lindhout,Higbee Jared Martin,Alan Kutach,William Joo,Zhengyu Gao,Diana Fu,Carmen To,Kalyani Mondal,Betty Chan Li,Avantika Kekatpure,Marilyn Wang,Teresa Laird,Geoffrey Horner,Jackie Chan,Michele McEntee,Manuel E. Lopez,Damodharan Lakshminarasimhan,Andre White,Sheng-Ping Wang,Jun Yao,Junming Yie,Hugo Matern,Mark J. Solloway,Raj Haldankar,Tom Parsons,Jie Tang,Wenyan D. Shen,Yu Alice Chen,Hui Tian,Bernard B. Allan +33 more
TL;DR: This work identifies glial cell-derived neurotrophic factor receptor alpha-like (GFRAL) as a brainstem-restricted receptor for growth and differentiation factor 15 (GDF15), and identifies a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress.
Journal ArticleDOI
Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84.
TL;DR: A role for GPR84 is indicated in directly linking fatty acid metabolism to immunological regulation and it is demonstrated that medium-chain FFAs amplify lipopolysaccharide-stimulated production of the proinflammatory cytokine interleukin-12 p40 through GPR 84.