H
Hui-Wen Chang
Researcher at National Taiwan University
Publications - 94
Citations - 2215
Hui-Wen Chang is an academic researcher from National Taiwan University. The author has contributed to research in topics: Porcine epidemic diarrhea virus & Virus. The author has an hindex of 19, co-authored 84 publications receiving 1820 citations. Previous affiliations of Hui-Wen Chang include Harvard University & Utrecht University.
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Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
Dan H. Barouch,James B. Whitney,Brian Moldt,Florian Klein,Thiago Y. Oliveira,Jinyan Liu,Kathryn E. Stephenson,Hui-Wen Chang,Karthik Shekhar,Sanjana Gupta,Joseph P. Nkolola,Michael S. Seaman,Kaitlin M. Smith,Erica N. Borducchi,Crystal Cabral,Jeffrey Y. Smith,Stephen Blackmore,Srisowmya Sanisetty,James R. Perry,Matthew Beck,Mark G. Lewis,William Rinaldi,Arup K. Chakraborty,Arup K. Chakraborty,Pascal Poignard,Michel C. Nussenzweig,Michel C. Nussenzweig,Dennis R. Burton,Dennis R. Burton +28 more
TL;DR: A profound therapeutic effect of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys as well as an impact on host immune responses are demonstrated.
Journal ArticleDOI
Spike Protein Fusion Peptide and Feline Coronavirus Virulence
TL;DR: Mutations can occur erratically and accompany tropism changes, resulting in unpredictable new diseases, and the environment can change rapidly to accommodate these changes.
Journal ArticleDOI
Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene
TL;DR: In this paper, the 3c gene was found to be mutated in the majority (71.4%) of FIPVs, but not in all, implying that mutation in 3c is not the (single) cause of the FIP.
Short Communication Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene
TL;DR: It is suggested that functional 3c protein expression is crucial for FECV replication in the gut, but dispensable for systemic FIPV replication, explaining the rare incidence of FIP outbreaks.
Journal ArticleDOI
Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha.
Hui-Wen Chang,Chian-Ren Jeng,Jiuan J. Liu,T.L. Lin,Chih-Cheng Chang,Mi-Yuan Chia,Yi-Chieh Tsai,Victor Fei Pang +7 more
TL;DR: It is suggested that swine AMs were an important reservoir of PCV2 and PRRSV and increased pro-inflammatory cytokine production may lead to a more severe pneumonic lesion in those dually infected pigs.