J
James B. Whitney
Researcher at Beth Israel Deaconess Medical Center
Publications - 67
Citations - 3808
James B. Whitney is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 26, co-authored 67 publications receiving 3358 citations. Previous affiliations of James B. Whitney include Jewish General Hospital & McGill University.
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Journal ArticleDOI
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
Dan H. Barouch,James B. Whitney,Brian Moldt,Florian Klein,Thiago Y. Oliveira,Jinyan Liu,Kathryn E. Stephenson,Hui-Wen Chang,Karthik Shekhar,Sanjana Gupta,Joseph P. Nkolola,Michael S. Seaman,Kaitlin M. Smith,Erica N. Borducchi,Crystal Cabral,Jeffrey Y. Smith,Stephen Blackmore,Srisowmya Sanisetty,James R. Perry,Matthew Beck,Mark G. Lewis,William Rinaldi,Arup K. Chakraborty,Arup K. Chakraborty,Pascal Poignard,Michel C. Nussenzweig,Michel C. Nussenzweig,Dennis R. Burton,Dennis R. Burton +28 more
TL;DR: A profound therapeutic effect of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys as well as an impact on host immune responses are demonstrated.
Journal ArticleDOI
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
James B. Whitney,Alison L. Hill,Srisowmya Sanisetty,Pablo Penaloza-MacMaster,Jinyan Liu,Mayuri Shetty,Lily Parenteau,Crystal Cabral,Jennifer L. Shields,Stephen Blackmore,Jeffrey Y. Smith,Amanda L. Brinkman,Lauren Peter,Sheeba I. Mathew,Kaitlin M. Smith,Erica N. Borducchi,Daniel I. S. Rosenbloom,Mark G. Lewis,Jillian Hattersley,Bei Li,Joseph Hesselgesser,Romas Geleziunas,Merlin L. Robb,Jerome H. Kim,Nelson L. Michael,Dan H. Barouch +25 more
TL;DR: It is demonstrated that the viral reservoir is seeded rapidly after intrarectal SIV infection of rhesus monkeys, during the ‘eclipse’ phase, and before detectable viraemia, which raises important new challenges for HIV-1 eradication strategies.
Journal ArticleDOI
Protective Efficacy of Adenovirus/Protein Vaccines Against SIV Challenges in Rhesus Monkeys
Dan H. Barouch,Dan H. Barouch,Galit Alter,Thomas Broge,Caitlyn Linde,Margaret E. Ackerman,Eric P. Brown,Erica N. Borducchi,Kaitlin M. Smith,Joseph P. Nkolola,Jinyan Liu,Jennifer L. Shields,Lily Parenteau,James B. Whitney,Peter Abbink,David Ng’ang’a,Michael S. Seaman,Christy L. Lavine,James R. Perry,Wenjun Li,Arnaud D. Colantonio,Mark G. Lewis,Bing Chen,Holger Wenschuh,Ulf Reimer,Michael Piatak,Jeffrey D. Lifson,Scott A. Handley,Herbert W. Virgin,Marguerite Koutsoukos,Clarisse Lorin,Gerald Voss,Mo Weijtens,Maria G. Pau,Hanneke Schuitemaker +34 more
TL;DR: Rhesus monkeys primed with Ad26 vectors expressing SIVsmE543 Env, Gag, and Pol and boosted with AS01B-adjuvanted Sivmac32H Env gp140 demonstrated complete protection in 50% of vaccinated animals against a series of repeated, heterologous, intrarectal SIVmac251 challenges that infected all controls.
Journal ArticleDOI
Zika viral dynamics and shedding in rhesus and cynomolgus macaques.
Christa E. Osuna,So-Yon Lim,Claire Deleage,Bryan D. Griffin,Derek R. Stein,Lukas T. Schroeder,Robert W Omange,Katharine Best,Ma Luo,Peter T. Hraber,Hanne Andersen-Elyard,Erwing Fabian Cardozo Ojeda,Scott Huang,Dana L. Vanlandingham,Stephen Higgs,Alan S. Perelson,Jacob D. Estes,David Safronetz,Mark G. Lewis,James B. Whitney,James B. Whitney +20 more
TL;DR: It is shown that both rhesus and cynomolgus macaques are highly susceptible to infection by lineages of Zika virus that are closely related to, or are currently circulating in, the Americas.
Journal ArticleDOI
Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys
Norman L. Letvin,Srinivas S. Rao,David C. Montefiori,Michael S. Seaman,Yue Sun,So-Yon Lim,Wendy W. Yeh,Mohammed Asmal,Rebecca Gelman,Ling Shen,James B. Whitney,Cathal Seoighe,Miguel Lacerda,Miguel Lacerda,Sheila M. Keating,Philip J. Norris,Michael G. Hudgens,Peter B. Gilbert,Adam P. Buzby,Linh Mach,Jinrong Zhang,Harikrishnan Balachandran,George M. Shaw,Stephen D. Schmidt,John Paul Todd,Alan Dodson,John R. Mascola,Gary J. Nabel +27 more
TL;DR: A vaccine protecting monkeys against mucosal infection by simian immunodeficiency virus sheds light on immune and genetic correlates of protection and highlights the need to scrutinize these types of correlates in future trials of HIV vaccines in human volunteers.