A Review on Biomedical Titanium Alloys: Recent Progress and Prospect

During the resorbable-polymer-boom of the 1970s and 1980s, polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices. Its popularity was soon superseded by faster resorbable polymers which had fewer perceived disadvantages associated with long term degradation (up to 3-4 years) and intracellular resorption pathways; consequently, PCL was almost forgotten for most of two decades. Recently, a resurgence of interest has propelled PCL back into the biomaterials-arena. The superior rheological and viscoelastic properties over many of its aliphatic polyester counterparts renders PCL easy to manufacture and manipulate into a large range of implants and devices. Coupled with relatively inexpensive production routes and FDA approval, this provides a promising platform for the production of longer-term degradable implants which may be manipulated physically, chemically and biologically to possess tailorable degradation kinetics to suit a specific anatomical site. This review will discuss the application of PCL as a biomaterial over the last two decades focusing on the advantages which have propagated its return into the spotlight with a particular focus on medical devices, drug delivery and tissue engineering.

The return of a forgotten polymer : Polycaprolactone in the 21st century

Progress in additive manufacturing on new materials: A review

Research status of laser cladding on titanium and its alloys: A review

Promoting the columnar to equiaxed transition and grain refinement of titanium alloys during additive manufacturing

Review of the biocompatibility of micro-arc oxidation coated titanium alloys

Research and development status of laser cladding on magnesium alloys: A review

Effect of process parameters on the microstructure evolution and wear property of the laser cladding coatings on Ti-6Al-4V alloy

Bone defects are a common disease threatening the health of many people. Calcium phosphate (CaP) is an ideal bone substitutive material that is widely used for bone repair due to its excellent biological properties including osteoinductivity, osteoconductivity and biodegradability. For this reason, investigation of these properties and the effects of various influencing factors is vital for modulating calcium phosphate during the design process to maximally satisfy clinical requirements. In this study, the latest studies on the biological properties of CaP biomaterials, including hydroxyapatite (HA), tricalcium phosphate (TCP), and biphasic calcium phosphate (BCP), have been summarized. Moreover, recent advances on how these properties are altered by different factors are reviewed. Considering the limited mechanical strength of CaP materials, this study also reviews CaP composites with different materials as improvement measures. Finally, perspectives regarding future developments of CaP materials are also provided.

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Huijun Yu

Papers

Research status of laser cladding on titanium and its alloys: A review

Review of the biocompatibility of micro-arc oxidation coated titanium alloys

Research and development status of laser cladding on magnesium alloys: A review

Effect of process parameters on the microstructure evolution and wear property of the laser cladding coatings on Ti-6Al-4V alloy

Biological properties of calcium phosphate biomaterials for bone repair: a review