Huixi Violet Zhang

TL;DR: It is shown that BRCA1 transactivates expression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in a p53-independent manner, and that B RCA1 inhibits cell-cycle progression into the S-phase following its transfection into human cancer cells.

TL;DR: In this paper, the computational design of physical (noncovalent) interactions with pathway-dependent, hierarchical "click" covalent assembly is combined to produce hybrid synthetic peptide-based polymers.

TL;DR: The findings illustrate that, with careful control of molecular structure and solution conditions, a single peptide motif can be versatile enough to yield a wide range of self-assembled lattice morphologies across many length scales (1 to 1000 nm).

TL;DR: This work demonstrates the successful use of assembly pathway control for the construction of nanostructures with diverse, well-structured morphologies associated with the folding and self-association of a single type of molecule.

TL;DR: In this article, two different peptide bundles were designed and examined, and the results showed that the coiled-coil tetramer was the dominant species in solution by analytical sedimentation studies and by small-angle neutron scattering, where the scattering form factor is well represented by a cylinder model with the dimensions of the targeted coiled coil.