Hun Young Kim

TL;DR: The cooperative catalyst activity between a chiral transition-metal catalyst and an achiral organocatalyst has been identified as one of the critical asymmetric reaction optimization components in the highly diastereo- and enantioselective aldol reaction of methyl α-isocyanoacetate.

TL;DR: The stepwise nature of the [3 + 2] cycloaddition reactions of N-metalated azomethine ylides has been demonstrated by highly enantio- and diastereoselective syntheses of exo-5 and endo-8 from the respective syn-4 and anti-7 conjugate addition products in a one-pot tandem fashion.

TL;DR: This work presents efforts to design a new asymmetric approach to the reversal of enantioselectivity in a catalytic asymmetric 1,3-dipolar cycloaddition reaction, based on the premise that chiral amino alcohol ligands should display different binding modes with different metals.

TL;DR: A new approach to both enantioenriched Henry products is developed by use of different molecularities of metal-ligand complexes generated from Cu(I) and Zn(II) metals with readily available chiral amino alcohol 1.

TL;DR: The rationale was based on the premise that solid supports would immobilize homogeneous chiral metal complexes, which are generated from rigid multifunctional brucine-derived ligands 1, through electrostatic interactions, and this mode is believed to provide a facile mechanism for inducing conformational changes with immobilized chiral complexes.