H
Husain Attarwala
Researcher at Northeastern University
Publications - 23
Citations - 945
Husain Attarwala is an academic researcher from Northeastern University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 17 publications receiving 707 citations. Previous affiliations of Husain Attarwala include Alnylam Pharmaceuticals.
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Journal ArticleDOI
An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia
Alfica Sehgal,Scott A Barros,Lacramioara Ivanciu,Brian C. Cooley,June Qin,Tim Racie,Julia Hettinger,Mary Carioto,Yongfeng Jiang,Josh Brodsky,Harsha K. Prabhala,Xuemei Zhang,Husain Attarwala,Renta Hutabarat,Don Foster,Stuart Milstein,Klaus Charisse,Satya Kuchimanchi,Martin Maier,Lubo Nechev,Pachamuthu Kandasamy,Alexander V Kel'in,Jayaprakash K. Nair,Kallanthottathil G. Rajeev,Muthiah Manoharan,Rachel Meyers,Benny Sørensen,Amy Simon,Yesim Dargaud,Claude Negrier,Rodney M. Camire,Akin Akinc +31 more
TL;DR: Treatment with ALN-AT3 promoted hemostasis in mouse models of hemophilia and led to improved thrombin generation in an NHP model of hemophile A with anti-factor VIII inhibitors.
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TGN1412: From Discovery to Disaster.
TL;DR: This review primarily deals with preclinical studies conducted by TeGenero, results of which encouraged them to test the antibody on human subjects, reasons why this drug failed in human trial and aftermath of this drug trial.
Journal ArticleDOI
Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.
Jayaprakash K. Nair,Husain Attarwala,Alfica Sehgal,Qianfan Wang,Krishna Aluri,Xuemei Zhang,Minggeng Gao,Ju Liu,Ramesh Indrakanti,Sally Schofield,Philip Kretschmer,Christopher R. Brown,Swati Gupta,Jennifer L. S. Willoughby,Julie A. Boshar,Vasant Jadhav,Klaus Charisse,Tracy Zimmermann,Kevin Fitzgerald,Muthiah Manoharan,Kallanthottathil G. Rajeev,Akin Akinc,Renta Hutabarat,Martin Maier +23 more
TL;DR: Compared two siRNAs of the same sequence but with different modification pattern resulting in different degrees of protection against nuclease activity enhanced stability translated into substantially improved liver exposure, gene silencing efficacy and duration of effect in mice.
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Multi-compartmental oral delivery systems for nucleic acid therapy in the gastrointestinal tract ☆
TL;DR: The results of these studies show that the multi-compartmental formulations can overcome many of the barriers for effective oral gene and siRNA delivery for the treatment of inflammatory bowel disease (IBD).
Journal ArticleDOI
Single-Dose Pharmacokinetics and Pharmacodynamics of Transthyretin Targeting N-acetylgalactosamine-Small Interfering Ribonucleic Acid Conjugate, Vutrisiran, in Healthy Subjects.
Bahru A. Habtemariam,Verena Karsten,Husain Attarwala,Varun Goel,Megan Melch,Valerie A. Clausen,Pushkal Garg,Akshay Vaishnaw,Marianne T. Sweetser,Gabriel J. Robbie,John Vest +10 more
TL;DR: The favorable pharmacokinetic, pharmacodynamic, and safety results observed here support vutrisiran's continued clinical development.