T
Tim Racie
Researcher at Alnylam Pharmaceuticals
Publications - 18
Citations - 1804
Tim Racie is an academic researcher from Alnylam Pharmaceuticals. The author has contributed to research in topics: Hepcidin & Anemia. The author has an hindex of 12, co-authored 18 publications receiving 1615 citations.
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Journal ArticleDOI
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
James E. Dahlman,Carmen M. Barnés,Omar F. Khan,Aude Thiriot,Siddharth Jhunjunwala,Taylor E. Shaw,Yiping Xing,Hendrik B. Sager,Gaurav Sahay,Lauren Speciner,Andrew Bader,Roman L. Bogorad,Hao Yin,Tim Racie,Yizhou Dong,Shan Jiang,Danielle Seedorf,Apeksha Dave,Kamaljeet Singh Sandhu,Matthew J. Webber,Tatiana Novobrantseva,Vera M. Ruda,Abigail K. R. Lytton-Jean,Christopher G. Levins,Brian T. Kalish,Dayna K. Mudge,Mario F. Perez,Ludmila Abezgauz,Partha Dutta,Lynelle P. Smith,Klaus Charisse,Mark W. Kieran,Kevin Fitzgerald,Matthias Nahrendorf,Dganit Danino,Rubin M. Tuder,Ulrich H. von Andrian,Akin Akinc,Dipak Panigrahy,Avi Schroeder,Victor Koteliansky,Robert Langer,Daniel G. Anderson +42 more
TL;DR: These nanoparticles mediate the most durable non-liver silencing reported so far and facilitate the delivery of siRNAs that modify endothelial function in mouse models of vascular permeability, emphysema, primary tumour growth and metastasis.
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
James E. Dahlman,Carmen M. Barnés,Omar F. Khan,Aude Thiriot,Siddharth Jhunjunwala,Taylor E. Shaw,Yiping Xing,Hendrik B. Sager,Gaurav Sahay,Lauren Speciner,Andrew Bader,Roman L. Bogorad,Hao Yin,Tim Racie,Yizhou Dong,Shan Jiang,Danielle Seedorf,Apeksha Dave,Kamaljeet Singh Sandhu,Matthew J. Webber,Tatiana Novobrantseva,Vera M. Ruda,Abigail K. R. Lytton-Jean,Christopher G. Levins,Brian T. Kalish,Dayna K. Mudge,Mario F. Perez,Ludmila Abezgauz,Partha Dutta,Lynelle P. Smith,Klaus Charisse,Mark W. Kieran,Kevin Fitzgerald,Matthias Nahrendorf,Dganit Danino,Rubin M. Tuder,Ulrich H. von Andrian,Akin Akinc,Dipak Panigrahy,Avi Schroeder,Victor Koteliansky,Robert Langer,Daniel G. Anderson +42 more
TL;DR: Polymeric nanoparticles made of low-molecular-weight polyamines and lipids can deliver siRNA to endothelial cells with high efficiency, thereby facilitating the simultaneous silencing of multiple endothelial genes in vivo.
Journal ArticleDOI
An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia
Alfica Sehgal,Scott A Barros,Lacramioara Ivanciu,Brian C. Cooley,June Qin,Tim Racie,Julia Hettinger,Mary Carioto,Yongfeng Jiang,Josh Brodsky,Harsha K. Prabhala,Xuemei Zhang,Husain Attarwala,Renta Hutabarat,Don Foster,Stuart Milstein,Klaus Charisse,Satya Kuchimanchi,Martin Maier,Lubo Nechev,Pachamuthu Kandasamy,Alexander V Kel'in,Jayaprakash K. Nair,Kallanthottathil G. Rajeev,Muthiah Manoharan,Rachel Meyers,Benny Sørensen,Amy Simon,Yesim Dargaud,Claude Negrier,Rodney M. Camire,Akin Akinc +31 more
TL;DR: Treatment with ALN-AT3 promoted hemostasis in mouse models of hemophilia and led to improved thrombin generation in an NHP model of hemophile A with anti-factor VIII inhibitors.
Journal ArticleDOI
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe -/- mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
Paul J. Schmidt,Ivanka Toudjarska,Anoop K. Sendamarai,Tim Racie,Stuart Milstein,Brian Bettencourt,Julia Hettinger,David Bumcrot,Mark D. Fleming +8 more
TL;DR: In this article, lipid nanoparticles (LNPs) were used to formulate Tmprss6 siRNA to increase hepatic expression of the iron-regulatory hormone hepcidin.
RED CELLS, IRON, AND ERYTHROPOIESIS An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe / mice and ameliorates anemia and iron overload in murine -thalassemia intermedia
Paul J. Schmidt,Ivanka Toudjarska,Anoop K. Sendamarai,Tim Racie,Stuart Milstein,Brian Bettencourt,Julia Hettinger,David Bumcrot,Mark D. Fleming +8 more
TL;DR: The results indicate that pharmacologic manipulation of Tmprss6 with RNAi therapeutics is a practical approach to treating iron overload diseases associated with diminished hepcidin expression and may have efficacy in modifying disease-associated morbidities of -thalassemia intermedia.