H
Harsha K. Prabhala
Researcher at University of Virginia
Publications - 8
Citations - 2918
Harsha K. Prabhala is an academic researcher from University of Virginia. The author has contributed to research in topics: Cadherin & Stromal cell. The author has an hindex of 6, co-authored 8 publications receiving 2779 citations. Previous affiliations of Harsha K. Prabhala include Johns Hopkins University & Alnylam Pharmaceuticals.
Papers
More filters
Journal ArticleDOI
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
Li Ma,Jennifer J. Young,Harsha K. Prabhala,Elizabeth Pan,Pieter Mestdagh,Daniel Muth,Julie Teruya-Feldstein,Ferenc Reinhardt,Tamer T. Onder,Scott Valastyan,Frank Westermann,Frank Speleman,Jo Vandesompele,Robert A. Weinberg +13 more
TL;DR: It is shown that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness, and a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
Li Ma,Jennifer J. Young,Harsha K. Prabhala,Elizabeth Pan,Pieter Mestdagh,Daniel Muth,Julie Teruya-Feldstein,Ferenc Reinhardt,Tamer T. Onder,Scott Valastyan,Frank Westermann,Frank Speleman,Jo Vandesompele,Robert A. Weinberg +13 more
TL;DR: In this article, the authors uncover a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasissuppressing protein E-cadherin.
Journal ArticleDOI
Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma.
Rao Prabhala,Dheeraj Pelluru,Mariateresa Fulciniti,Harsha K. Prabhala,Puru Nanjappa,Weihua Song,Christine Pai,Samir B. Amin,Yu-Tzu Tai,Paul G. Richardson,Irene M. Ghobrial,Steven P. Treon,John F. Daley,Kenneth C. Anderson,Kenneth C. Anderson,Jeffery L. Kutok,Nikhil C. Munshi,Nikhil C. Munshi,Nikhil C. Munshi +18 more
TL;DR: IL-17-producing T(h)17 cells play an important role in MM pathobiology and may be an important therapeutic target for anti-MM activity and to improve immune function.
Journal ArticleDOI
An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia
Alfica Sehgal,Scott A Barros,Lacramioara Ivanciu,Brian C. Cooley,June Qin,Tim Racie,Julia Hettinger,Mary Carioto,Yongfeng Jiang,Josh Brodsky,Harsha K. Prabhala,Xuemei Zhang,Husain Attarwala,Renta Hutabarat,Don Foster,Stuart Milstein,Klaus Charisse,Satya Kuchimanchi,Martin Maier,Lubo Nechev,Pachamuthu Kandasamy,Alexander V Kel'in,Jayaprakash K. Nair,Kallanthottathil G. Rajeev,Muthiah Manoharan,Rachel Meyers,Benny Sørensen,Amy Simon,Yesim Dargaud,Claude Negrier,Rodney M. Camire,Akin Akinc +31 more
TL;DR: Treatment with ALN-AT3 promoted hemostasis in mouse models of hemophilia and led to improved thrombin generation in an NHP model of hemophile A with anti-factor VIII inhibitors.
Book ChapterDOI
Anti-Inflammatory Natural Foods
TL;DR: Clinical and cellular evidence are integrated to provide a comprehensive basis explaining how a broad spectrum of dietary components can exert protective effects against the persistent pathologies of inflammation.