H
Huveyda Basaga
Researcher at Sabancı University
Publications - 73
Citations - 3164
Huveyda Basaga is an academic researcher from Sabancı University. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 28, co-authored 72 publications receiving 2881 citations. Previous affiliations of Huveyda Basaga include University of Turin & Middle East Technical University.
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Journal ArticleDOI
Pathological aspects of lipid peroxidation
Anne Nègre-Salvayre,Nathalie Augé,Victoria Ayala,Huveyda Basaga,Jordi Boada,Rainer Brenke,Sarah J. Chapple,Guy Cohen,János Fehér,Tilman Grune,Gabriella Lengyel,Giovanni E. Mann,Reinald Pamplona,Giuseppe Poli,Manuel Portero-Otin,Yael Riahi,Robert Salvayre,Shlomo Sasson,José C. E. Serrano,Ofer Shamni,Werner Siems,Richard C.M. Siow,Ingrid Wiswedel,Kamelija Zarkovic,Neven Zarkovic +24 more
TL;DR: Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.
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Tumor suppressor genes and ROS: complex networks of interactions.
TL;DR: These important interactions indicate a critical potential role for tumor suppressor genes in the cellular response against oxidative stress and emphasize links between ROS and tumor suppressionor genes that might be therapeutic targets in oxidative damage-associated diseases.
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Lipid oxidation products in cell signaling.
Gabriella Leonarduzzi,Melek C. Arkan,Melek C. Arkan,Huveyda Basaga,Elena Chiarpotto,Alex Sevanian,Giuseppe Poli +6 more
TL;DR: Among the lipid oxidation products detectable in ox-LDLs, and also in the atherosclerotic plaques, 4-hydroxynonenal has been widely investigated and was shown to upregulate AP-1 transcription factor, signaling through the MAP kinase pathway, with eventual nuclear localization and induction of a series of genes.
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Biochemical aspects of free radicals
TL;DR: The reactivity of both primary and secondary radicals with biomolecules and in whole tissue systems is of interest, not only because of their importance in radiobiology but also because of the role these species play in toxicity and various disorders.
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Inflammation meets oxidation: NF-κB as a mediator of initial lesion development in atherosclerosis
Ozgur Kutuk,Huveyda Basaga +1 more
TL;DR: The authors address NF-kappaB as a major therapeutic target, especially for preventive measures, in the light of two main hypotheses of atherosclerosis: oxidation and inflammation.