R
Reinald Pamplona
Researcher at University of Lleida
Publications - 295
Citations - 14797
Reinald Pamplona is an academic researcher from University of Lleida. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 63, co-authored 259 publications receiving 12729 citations. Previous affiliations of Reinald Pamplona include Max Planck Society & Hospital Universitari Arnau de Vilanova.
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Journal ArticleDOI
Life and death: metabolic rate, membrane composition, and life span of animals.
TL;DR: The links between metabolic rate andmaximum life span of mammals and birds as well as the linking role of membrane fatty acid composition in determining the maximum life span are reviewed.
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A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
Karim S. Echtay,Telma C. Esteves,Julian L. Pakay,Mika B. Jekabsons,Adrian J. Lambert,Manuel Portero-Otin,Reinald Pamplona,Antonio Vidal-Puig,Steven Wang,Stephen J. Roebuck,Martin D. Brand +10 more
TL;DR: The findings indicate that hydroxynonenal is not merely toxic, but may be a biological signal to induce uncoupling through UCPs and ANT and thus decrease mitochondrial ROS production.
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Pathological aspects of lipid peroxidation
Anne Nègre-Salvayre,Nathalie Augé,Victoria Ayala,Huveyda Basaga,Jordi Boada,Rainer Brenke,Sarah J. Chapple,Guy Cohen,János Fehér,Tilman Grune,Gabriella Lengyel,Giovanni E. Mann,Reinald Pamplona,Giuseppe Poli,Manuel Portero-Otin,Yael Riahi,Robert Salvayre,Shlomo Sasson,José C. E. Serrano,Ofer Shamni,Werner Siems,Richard C.M. Siow,Ingrid Wiswedel,Kamelija Zarkovic,Neven Zarkovic +24 more
TL;DR: Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.
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Hyperglycemia and glycation in diabetic complications.
TL;DR: The mechanism of glycation and of AGEs formation and the role of hyperglycemia, A GEs, and oxidative stress in the pathophysiology of diabetic complications are summarized.
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Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity.
TL;DR: The causal role of ALEs in aging and longevity is inferred from the findings that follow: a) its accumulation with aging in several tissues and species; b) physiological interventions that increase longevity, decrease ALEs content; c) the longer the longevity of a species, the lower is the lipoxidation-derived molecular damage; and finally d) exacerbated levels of ALES are associated with pathological states.