Hye Jin Kang

TL;DR: This study illustrates the opportunities for modulating melatonin receptor biology through MT 1 -selective ligands and for the discovery of previously undescribed, in vivo active chemotypes from structure-based screens of diverse, ultralarge libraries.

TL;DR: Neither ketamine’s enantiomers nor its metabolites had affinity for DA receptors or the DA, noradrenaline, and serotonin transporters (up to 10 μM), suggesting that neither the side effects nor antidepressant actions of ketamine or ketamine metabolites are associated with direct effects on mesolimbic DAergic neurotransmission.

TL;DR: The MRGPRX family of receptors as mentioned in this paper is a family of mas-related G-protein-coupled receptors that have evolved relatively recently and are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions.

TL;DR: A cell‐based screening assay that uses fluorescence microscopy to identify apelin receptor (APJ) antagonists is developed and demonstrates a new pharmacologic property of protamine—blockade of APJ—that could explain some adverse effects observed in protamine‐treated patients.

TL;DR: The design and synthesis of a radiolabeled negative allosteric modulator (NAM) for mGlu2 PET tracer development based on a quinoline 2-carboxamide scaffold is reported, and [11C]QCA is a chemical probe that provides the basis for the development of a new generation mGLU2PET tracers.