H
Hyun-Mi Ko
Researcher at Chonnam National University
Publications - 41
Citations - 1059
Hyun-Mi Ko is an academic researcher from Chonnam National University. The author has contributed to research in topics: Platelet-activating factor & Vascular endothelial growth factor. The author has an hindex of 20, co-authored 41 publications receiving 979 citations. Previous affiliations of Hyun-Mi Ko include Chonbuk National University & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Molecular Mechanisms for Lipopolysaccharide-induced Biphasic Activation of Nuclear Factor-κB (NF-κB)
Su-Ji Han,Hyun-Mi Ko,Jung-Hwa Choi,Kook Heon Seo,Hyun-Suk Lee,Eun Kyoung Choi,Il-Whan Choi,Hern-Ku Lee,Suhn-Young Im +8 more
TL;DR: It is found that TNF and IL-1β had a role in the second phase activation of NF-κB, and these cytokines did promote the synthesis of platelet-activating factor, which in turn induced the secondary activation of NPKB.
Journal Article
Augmentation of Tumor Metastasis by Platelet-activating Factor
Suhn-Young Im,Hyun-Mi Ko,Yoo-Seung Ko,Jung-Woo Kim,Hern-Ku Lee,Tai-You Ha,Hwanghee Blaise Lee,Sang-Jin Oh,Suk Bai,Ki-Chul Chung,Young-Bo Lee,Hyen-Sam Kang,Soon-Bai Chun +12 more
TL;DR: PAF has a metastasis-enhancing effect and is a mediator of the metastatic activities of TNF-alpha and IL-1alpha, and Neutralization of endogenous PAF with PAF antagonist BN50739 decreased lung colonization, suggesting that endogenous PAf plays an important role in pulmonary metastases.
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Administration of antisense phosphorothioate oligonucleotide to the p65 subunit of NF-κB inhibits established asthmatic reaction in mice
TL;DR: Evidence is provided that NF-kappaB plays a critical role in the pathogenesis of asthma in mice, and two successive intravenous administration of p65 antisense before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions, whereas the p65 nonsense did not produce such effects.
Journal Article
Nuclear Factor κB Dependency of Platelet-activating Factor-induced Angiogenesis
Hyun-Mi Ko,Kook Heon Seo,Su-Ji Han,Kyu Youn Ahn,Il-Hwan Choi,Gou Young Koh,Hern-Ku Lee,Myung Suk Ra,Suhn-Young Im +8 more
TL;DR: It is indicated that PAF enhances angiogenesis through inducing NFκB activation, which in turn promotes the production of angiogenic factors such as VEGF.
Journal ArticleDOI
Estrogen Enhances Angiogenesis through a Pathway Involving Platelet-Activating Factor-Mediated Nuclear Factor-κB Activation
Kook Heon Seo,Hyun-Suk Lee,Bongnam Jung,Hyun-Mi Ko,Jung-Hwa Choi,Sung Jun Park,Il-Hwan Choi,Hern-Ku Lee,Suhn-Young Im +8 more
TL;DR: The results suggest that estrogen induces the production of angiogenic factors via a mechanism involving PAF-mediated NF-κB activation, and PLA2 expression is the upstream pathway in the estrogen-induced angiogenesis.