Showing papers in "International Immunopharmacology in 2004"

TL;DR: The mechanism to which specific cells of the immune system recognize endotoxin and the resulting pathways leading to nuclear factor-kappaB activation and proinflammatory gene transcription are analyzed, and the involvement of reactive oxygen and nitric oxide and the protective role of antioxidants are focused on.

TL;DR: Different pulp structural components are associated with different polysaccharides and thus may potentially be different functionally, which may help lay a basis for better controlled processing methods and applications for this well-accepted medicinal plant.

TL;DR: The modulation of a polysaccharide-protein complex from Lycium barbarum (LBP3p) on the immune system in S180-bearing mice suggests that L BP3p at 10 mg/kg has a highly significant effect on tumor weight and improves theimmune system.

TL;DR: Wang et al. as discussed by the authors studied the effects of Chinese herbal medicinal ingredients (CHMIs) on peripheral lymphocyte proliferation and serum antibody titer in chicken vaccinated with Newcastle disease (ND) vaccine.

TL;DR: The high levels of expression of IL-22R1 observed in epithelial cells of the colon and the ability ofIL-22 to upregulate production of acute phase proteins and IL-10 in Colo205 cells, suggest a functional role for IL- 22 in intestinal inflammation.

TL;DR: The water solubility, high molecular mass, activation of lymphocytes especially NK cells, complement activation, Th1 pathway-associated cytokine profile, together with a low level of nitric oxide synthesis and absence of oxidative stress confer important immunoprotective potential to this novel α-d-glucan.

TL;DR: Results suggest that CAPE could have immunomodulatory effects in vivo, and CD4(+) T cell subsets are significantly increased in exposure to CAPE.

TL;DR: The results suggest that GL-related compounds are effective in reducing chemokine production and thatGL-modified compounds including hetero-30-OH-GL and homo- 30- OH-GL appear most beneficial in view of their inhibitory capacity with less cytotoxicity.

TL;DR: Results indicate that MA modulates the expression of a large number of genes that are critical for the regulation of apoptosis, viral replication, tumorogenesis, inflammation and various autoimmune diseases, and raise the possibility that it may be of value in the treatment of inflammatory diseases and/or cancer.

TL;DR: Residual levels of total IgG over 600 mg/dl may help prevent progression of lung damage in patients with CVID and levels of IgG, clinical manifestations and PFTs seem sufficient for routine follow-up.

TL;DR: Phycarine increased NK cell-mediated killing of tumor cells both in vitro and in vivo while acting via complement receptor type 3 (CR3) receptors.

TL;DR: Results suggest that mast cells accumulated at the wound edge may participate in tissue remodeling in the late phase of wound healing.

TL;DR: There is considerable variation in the signals and requisite cellular metabolic events necessary to induce apoptosis in diverse cell types, but the morphological features associated with apoptosis are highly conserved.

TL;DR: Data point to a function of the novel IL-10 family members in communication and interaction between cells of the hematopoietic and non-hematopoetic lineages, a role quite distinct from the immunomodulating effects ofIL-10 itself.

TL;DR: Mda-7 is a unique multifunctional cytokine in the IL-10 family and may have potent antitumor utility in a clinical setting and the "bystander" effects proposed for MDA-7/IL-24 protein include immune stimulation, antiangiogenesis and receptor-mediated cytotoxicity.

TL;DR: Piperine at a concentration of 2.5, 5 and 10 μg/ml inhibited the collagen matrix invasion of B16F-10 melanoma cells in a dose-dependent manner and the nuclear translocation of p65, p50, c-Rel subunits of NF-κB and other transcription factors were inhibited by the treatment of piperine.

TL;DR: It is suggested that IL-19 is able to influence the maturation of human T-cells and up-regulated IL-4 and down-regulated IFNgamma in a dose-dependent manner.

TL;DR: Functional studies revealed significant hematopoietic activity by both pharmacologic and molecular analysis using a >99% pure carbohydrate fraction from Aloe vera gels, suggesting the potential for diverse pharmacologic activity.

TL;DR: Results showed that arctigenin inhibited activation of MAP kinases including ERK1/2, p38 kinase and JNK through the inhibition of MKK activities, leading to AP-1 inactivation, which might, at least in part, contribute to the inhibited of TNF-alpha production.

TL;DR: Investigation of the effects of antidepressant agents on the production of the pleotrophic cytokines TNF-alpha and IL-6 found that IL- 6 production was significantly higher in depressed patients than in age-matched volunteers, whereas T NF-alpha production was significant higher in older volunteers than in younger ones.

TL;DR: The study showed that dexamethasone may exert a neuroprotective effect towards neurons injured by MPTP, but only when used in a proper dose.

TL;DR: It is suggested that paeonol has antianaphylatic activity by regulating histamine and TNF-alpha and its mode of action is elucidated.

TL;DR: The responses that have been observed to date for IL-22 resemble the "acute phase" type responses elicited by IL-6, suggesting thatIL-22 might be appropriately considered as a T cell-derived IL- 6-like activity having distinct target cell specificity.

TL;DR: A dichotomous regulation of these important proinflammatory mediators by PD and PD3 is suggested, suggesting that PD may stimulate TNF-alpha synthesis or inhibit degradation of T NF-alpha mRNA.

TL;DR: It is found that CQ-mediated protection of lethal challenge by CpG ODN and LPS was associated with the reduction of proinflammatory cytokine release from the cells.

TL;DR: It is demonstrated that concentrations of caffeine that are relevant to human consumption consistently suppress production of the proinflammatory cytokine TNF-alpha in human blood and that this effect is mediated by the cyclic AMP/protein kinase A pathway.

TL;DR: The conditional tumor growth retardation, observed in mice treated with NLP before tumor inoculation, may be regulated by NLP mediated immune activation, having prominent role in the cellular immune function of the tumor host.

TL;DR: The results suggest that ginsenoside Rg1 is a desirable agent for enhancing CD4(+) T-cell activity, as well as the correction of Th1-dominant pathological disorders.

TL;DR: It appears that all members of the class II cytokine receptor family (CRF2) have been identified and partially characterized, and signaling events induced through various combinations of CRF2 subunits partially overlap, leading to the induction of overlapping but cytokine-specific biological activities.

TL;DR: CVT-E002 significantly increased Con-A-induced IL-2 and IFN-gamma productions in spleen cells in a dose-dependent manner and response was seen by the ginseng extract originated from three different lots, suggesting consistency between the lots.